Keunsun Ahn received B.S. in Mechanical Engineering from Soongsil University(South Korea) and M.S. in Mechanical Engineering(3D printing and Tissue Engineering) from Pohang University of Science and Technology(POSTECH, South Korea). K. Ahn has a lot of research and development(R&D) experiences in bio/medical applications of 3D printing/Bioprinting technology, and had worked for T&R Biofab Co., Ltd., a representative startup in South Korea, and conducted R&D in the field of 3D bioprinter development and bio-printed cell therapy. Since then, K. Ahn has been commercializing cell spheroid production automation and spheroid-derived extracellular vesicle production technology as Founder & CEO of SPHEBIO Co., Ltd., which is established in 2020. K. Ahn have published 50 domestic/international patents and 20 journal papers.
Efficient Production of Extracellular Vesicles Using Cell Spheroids
Tuesday, 14 December 2021 at 13:30
Add to Calendar ▼2021-12-14 13:30:002021-12-14 14:30:00Europe/LondonEfficient Production of Extracellular Vesicles Using Cell SpheroidsExtracellular Vesicles (EVs): Technologies and Biological Investigations in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Cell-derived extracellular vesicles(EVs) contain miRNA, mRNA, and various proteins, and many studies have been conducted on the therapeutic potential due to their intracellular communication capabilities. However, for commercial use, it is necessary to improve the production efficiency and quality control standards of existing EV production technology. Here, we have developed EV production technology using cell aggregates/spheroids to improve EV production efficiency. Since the EV production environment changes according to the size of the cell spheroid used for EV production, we developed cell spheroid production automation technology to produce uniform cell spheroids. The production of EVs derived from cell spheroids significantly increased the production index of number of EVs per cell(# of EVs/cell) compared to the conventional 2D cell culture, and a change in productivity was confirmed depending on the size. The results of this study could suggest mass production technology for EV commercialization.
Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonExtracellular Vesicles (EVs): Technologies and Biological InvestigationsExtracellular Vesicles (EVs): Technologies and Biological Investigations in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2021-12-14 13:30:002021-12-14 14:30:00Europe/LondonEfficient Production of Extracellular Vesicles Using Cell SpheroidsExtracellular Vesicles (EVs): Technologies and Biological Investigations in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
