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SELECTBIO Conferences Biofabrication & Biomanufacturing 2022

Julianne Holloway's Biography

Julianne Holloway, Assistant Professor of Chemical Engineering, Arizona State University

Julianne Holloway is an Assistant Professor of Chemical Engineering at Arizona State University (ASU) and an associate faculty member within the Biodesign Institute’s Center for Molecular Design and Biomimetics. Prior to ASU, Julianne completed her Ph.D. in Chemical Engineering at Drexel University and her postdoctoral training at the University of Pennsylvania. Julianne’s research group integrates biomaterial design with innovative manufacturing to control and direct stem cell behavior for tissue engineering and regenerative medicine applications. Julianne is also committed to service, including recent election to the American Institute of Chemical Engineers (AIChE) Board of Directors, serving on the Editorial Board of Regenerative Biomaterials, and as a past Associate Scientific Advisor for Science Translational Medicine. Her contributions have been recognized through several awards, including: AIChE’s 35 Under 35 Award, AIChE’s John C. Chen Leadership Award, Mayo Clinic-ASU Alliance Faculty Summer Fellow, National Institutes of Health NRSA Postdoctoral Fellowship, and others.

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Combining Magnetically-assisted Electrospinning with Photoconjugation to Create Multi-Gradient Biomaterials

Tuesday, 22 March 2022 at 14:00

Add to Calendar ▼2022-03-22 14:00:002022-03-22 15:00:00Europe/LondonCombining Magnetically-assisted Electrospinning with Photoconjugation to Create Multi-Gradient BiomaterialsBiofabrication and Biomanufacturing 2022 in

There have been significant advances within tissue engineering; nonetheless, translation has proven difficult with ongoing challenges regenerating complex tissues with a heterogeneous structure and multiple cell types. For example, the interfacial tissue between adjacent tissues (e.g. tendon-bone, ligament-bone, cartilage-bone) has complex gradients of structure, cell type, and chemical composition. Designing biomaterial scaffolds that mimic the heterogeneous properties of these interfacial tissues is vital for spatially controlling cell behavior and promoting functional tissue regeneration. Towards this aim, we have developed an innovative manufacturing technique to selectively and precisely control gradients in fiber alignment and chemistry. First, magnetically-assisted electrospinning was used to control fiber alignment. Electrospun fibers were highly aligned in the presence of a magnetic field and transitioned to randomly aligned fibers away from the magnetic field. Using different magnet configurations, we were able to spatially control the degree and direction of fiber alignment. Second, post-electrospinning photoconjugation was used to create gradients in fiber chemistry. To mimic the mineralization gradient present in the tendon-bone interface, we conjugated a calcium-binding peptide to the fibrous scaffold. Following incubation in simulated body fluid, mineralization selectively occurred only in areas where the calcium-binding peptide was present. Combined, these two techniques provide precise spatial control over fiber alignment and mineralization to create dual gradient fibrous scaffolds that mimic the tendon-bone interface.

Add to Calendar ▼2022-03-21 00:00:002022-03-22 00:00:00Europe/LondonBiofabrication and Biomanufacturing 2022Biofabrication and Biomanufacturing 2022 in