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SELECTBIO Conferences Extracellular Vesicles 2023: Drug Delivery, Biologics & Therapeutics

Natalia Higuita-Castro's Biography

Natalia Higuita-Castro, Associate Professor, The Ohio State University

Dr. Higuita-Castro is an Associate Professor in the Department of Biomedical Engineering at The Ohio State University (OSU). She obtained her Ph.D. in Biomedical Engineering from OSU, where she spearheaded the development of novel models to simulate the alveolar microenvironment and their implementation to characterize cellular and inflammatory responses during mechanical ventilation, as well as the study of novel pharmaco-protective and biomolecular therapies for ventilator induced lung injury. During her postdoctoral training at the Department of Surgery and the Division of Pulmonary, Critical Care, and Sleep Medicine at the OSU Wexner Medical Center, she participated and led interdisciplinary research in the fields of lung inflammation, miRNA therapeutics, and direct cell reprogramming. Dr. Higuita-Castro is a HHMI Med into Grad scholar, and an American Heart Association and NIH T32 fellow. Dr. Higuita-Castro’s research focuses on Nanomedicine and Extracellular Vesicle (EV)-based nanocarriers for therapeutic applications, including lung injury and back pain. Over the past years, this effort has yielded multiple intellectual property filings led or co-led by her lab. Dr. Higuita-Castro’s work highlights the significant potential of engineered EVs as next generation nanocarriers for gene therapy applications.

Natalia Higuita-Castro Image

Engineered Extracellular Vesicles for Therapeutic Applications

Thursday, 27 July 2023 at 18:15

Add to Calendar ▼2023-07-27 18:15:002023-07-27 19:15:00Europe/LondonEngineered Extracellular Vesicles for Therapeutic ApplicationsExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando,

Over the past two decades, nanoscale technologies have emerged as a promising tool to enable groundbreaking biomedical research and translational applications. This seminar will focus on discussing the use of nanotechnology-enabled strategies to develop novel nanocarriers based on engineered extracellular vesicles (EVs) to target cell populations in the lung, brain, and intervertebral disc (IVD). EVs are cell-derived carriers that share molecular cues with their donor cell and play a crucial role in cell signaling under healthy and pathological conditions. The implementation of engineered EVs as next-generation non-viral nanocarriers for gene and drug delivery helps to circumvent major practical and translational barriers inherent to other delivery methodologies, such as capsid size and redosing restrictions for viral vectors. Our data highlights the potential of engineered EVs to drive direct reprogramming processes of somatic cells towards induced endothelial or neuronal tissue, as well as their ability to reduce inflammation and facilitate tissue repair/regeneration.

Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Drug Delivery, Biologics and TherapeuticsExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando,