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SELECTBIO Conferences 2D-to-3D Culture and Organoids 2020

Shay Soker's Biography



Shay Soker, Professor of Regenerative Medicine, Wake Forest Institute for Regenerative Medicine

Dr. Shay Soker is a Professor of Regenerative Medicine at the Wake Forest Institute for Regenerative medicine and an affiliated Professor of Cancer Biology, Physiology & Pharmacology, Biomedical Engineering and Surgical Sciences. Dr. Soker developed programs in neo-vascularization of bioengineered tissues, including angiogenic gene transfer to enhance tissue vascularization, cell therapy using vascular cells and ex-vivo revascularization of bioengineered tissues and organs. His stem cell research focuses on the identification and isolation of stem cells from different sources, including adult and fetal stem cells from amniotic fluid and placenta, and their directed differentiation to generate tissues in vitro and in vivo. In parallel, Dr. Soker’s group is exploring tissue-derived extracellular matrices as scaffolds for whole organ bioengineering. Recently, Dr. Soker applied 3D tissue engineering and bioprinting technologies to develop small 3D tissue constructs (organoids) for studying tissue development, as human disease models, for drug toxicity testing and drug discovery. Some of Dr. Soker’s projects are now being discussed with industry collaborators in order to create new regenerative medicine product.

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Tissue Organoids For Disease Modeling

Wednesday, 25 March 2020 at 16:15

Add to Calendar ▼2020-03-25 16:15:002020-03-25 17:15:00Europe/LondonTissue Organoids For Disease Modeling2D-to-3D Culture and Organoids 2020 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com

Traditional in vitro two dimensional (2D) cell cultures fail to recapitulate the microenvironment of in vivo tissues. They have three major differences from native tissue microenvironments: substrate topography, substrate stiffness, and most importantly, a 2D rather than three dimensional (3D) architecture. In contrast, 3D human tissue organoids replicate native tissue structure and function and thus are superior to traditional 2D cultures and animal models. These organoids can be studied in vitro for several weeks to allow intensive investigations. Besides their advantages in drug toxicity testing and for development of new drugs, the human tissue organoid platform serves as a model system to explore human tissue development and disease. Our recent research was focused on the use of human tissue organoids to study liver development and congenital diseases as well as other common diseases such as tissue fibrosis and cancer. Altogether our human tissue organoids system can be used for modeling of a wide verity of diseases and develop new personalized/precision medicine applications.


Add to Calendar ▼2020-03-25 00:00:002020-03-26 00:00:00Europe/London2D-to-3D Culture and Organoids 20202D-to-3D Culture and Organoids 2020 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com