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SELECTBIO Conferences Lab-on-a-Chip & Microfluidics 2019: Emerging Themes, Technologies and Applications Track "A"

Hsueh-Chia Chang's Biography

Hsueh-Chia Chang, Bayer Professor of Engineering, University of Notre Dame

H-C (Chia) Chang is a leader in electrokinetics, an important micro/nanofluidic technology for biochip platforms in future disease diagnostic products. His approach combines insightful theoretical analysis with simple but creative experiments to uncover new electrokinetic phenomena or to verify speculated ones. These new phenomena then led to inventions in new molecular diagnostics that use non-equilibrium electrokinetics and field-focusing physics to dramatically improve the performance of equilibrium probe-based assays without external fields. He and his PhD and postdoc students are inventors of 10 Notre Dame patents and 6 provisional patents, the largest IP output from any lab at Notre Dame. Five technologies have been licensed by startups near Notre Dame. One startup FCubed LLC will be going public this year. Another startup AgenDx has just licensed another of his technologies. Since 2000, 18 PhD and post-doc students of the Chang laboratory have embarked on academic careers as tenure-track professors at Chemical Engineering, Mechanical Engineering, Electrical Engineering, Food Science, Chemistry departments in 5 continents. Chia is the coauthor of a seminal book on Electrokinetics and he is the Founding Editor of Biomicrofluidics, the first American Institute of Physics journal in biology. He has published over 270 articles with 13,000 citations and an H-index of 63.

Hsueh-Chia Chang Image

Droplet Emulsion Generation based on Electrokinetics: Digital PCR and Cell Encapsulation

Wednesday, 9 October 2019 at 09:00

Add to Calendar ▼2019-10-09 09:00:002019-10-09 10:00:00Europe/LondonDroplet Emulsion Generation based on Electrokinetics: Digital PCR and Cell

We report a new microdroplet generation technology that uses AC electric field rather than hydrodynamic shear to generate droplets. Intricate flow-rate tuning of both phases is hence unnecessary and massive parallelization is now possible because of the absence of hydrodynamic cross-talk.   The bulky and expensive precision micropump is replaced by a simple and miniature AC source that can be driven by a battery.  With a less viscous oil phase and a properly tuned AC frequency, we are able to eliminate electro-coalescence and Rayleigh fission.  Monodispersed droplets with CV less than 3% and with a size range from 10 to 100 microns can be generated at a high throughput of nearly 1000 Hz per nozzle.  Moreover, the size of the droplets can be easily adjusted by simply tuning the voltage or the frequency.  One hundred to one million droplets and, with parallelization,  more than 1 billion droplets can be generated in 30 minutes.  This large range allows high-dynamic range digital PCR and conformal cell encapsulation.

Add to Calendar ▼2019-10-07 00:00:002019-10-09 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics 2019: Emerging Themes, Technologies and Applications Track "A"