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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

Dong Pyo Kim's Biography



Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH)

Prof. Dong-Pyo Kim is a professor of POSTECH Chemical Engineering department, and also a director of the National Creative Research Center for Intelligent Microprocess of Pharmaceutical Synthesis. He obtained Ph.D. in chemistry at Temple University in 1991, then post-doctoral research in University of Illinois at Urbana-Champaign (Materials Science & Engineering), and joined Korea Research Institute of Chemical Technology as a senior researcher. Prior to POSTECH at 2012, he had worked in Applied Chemistry at Chungnam Nat. University for 17 years. His microfluidic research has been rooted at materials chemistry of silicon-based resin (preceramic polymers, sol-gel). Since 2004, he has devoted to a microreaction field, covering the reactor design, fabrication as well as continuous-flow syntheses in organics, polymers and nanomaterials, currently focusing at scale-up microreactor for production of API and drug delivery systems.

Throughout a long endeavor, he published at journal Science (2016). The chip microreactor embedded with rapid mixing design enabled to handle a life time of highly unstable lithiated intermediates in the submillisecond range, which outpaced the rapid anionic Fries rearrangement and applied to the synthesis of a bioactive molecule.

He has published >250 peer-reviewed papers and 30 patents. He received Academic Excellence Award by Korean Chemical Society (2017), POSTECHIAN of the Year (2016, POSTECH), The Great Scientist Award (2016) and Best 100 Scientific Achievement (2014, 2007) by National Research Foundation. He was appointed as a Yonsan chaired professor by POSTECH at 2017.

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Microfluidic Approaches for Scale-up Chemical Production via Numbering-up & Ultrafast Chemistry

Thursday, 10 September 2020 at 14:00

Add to Calendar ▼2020-09-10 14:00:002020-09-10 15:00:00Europe/LondonMicrofluidic Approaches for Scale-up Chemical Production via Numbering-up and Ultrafast ChemistryMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Continuous-flow technology is emerging for efficient, sustainable and safe synthesis of drug and the precursors. In here, scale-up chemical production are efficiently demonstrated by adopting both approaches of numbering-up microreactors and ultrafast chemical synthesis at high flow rates. Firstly, various numbering-up microreactor systems were designed and manufactured with stainless steel metal or polymer films. The compact and robust reactors demonstrated scale-up production of several drug compounds via azide-alkyne reaction, fast synthesis of organophosphates. Moreover, photocatalysis in a multi-capillary assembly system, 3D printed reactors were used to improve the synthetic productivity. Alternatively, ultrafast synthetic approaches were performed by taming the lithiated flash chemistry in unique microreactors at high flow rates, which envisions facile scale-up production of drugs. Unique design of a chip microreactor enabled submillisecond mixing time even at low temperatures, which was used for outpacing rapid intramolecular rearrangements such as anionic Fries rearrangement to attain high chemoselectivity. And 3D-printed stainless steel microreactor with circular shape of cross-sectional fluidic channel enhanced the intramolecular control for higher yield of the un-rearranged product. Further, a 16 stacked reactor system of circular channel structure with superior mixing efficiency was alternatively devised to synthesize commercial Letrozole drug by newly developed 3 steps route, including ~10 milliseconds of flash chemistry.


Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com