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SELECTBIO Conferences Fragment Based Lead Discovery

Gregg Siegal's Biography

Gregg Siegal, Professor, Leiden University

Dr. Siegal obtained his Ph.D. on studies of eukaryotic DNA replication at the University of Rochester in the USA. Pursuing an interest in structural biology he moved to the laboratory of Professor Kurt Wüthrich at the ETH in Zürich, Switzerland. His work in the Wüthrich group focused on heteronuclear NMR studies of protein structure and folding. Subsequently he joined the group of Professor Paul Driscoll at the Ludwig Institute of Cancer Research in London, UK where he studied protein structure and small molecule interactions, again using NMR. He moved to Leiden University in 1997 where he received a Dutch Royal Society Fellowship to form his own research group. His current research interests focus on development of drug discovery technologies and their implementation in the drug discovery process. In 2004 he spun out the company ZoBio to commercialize the TINS ligand screening technology developed in his group and presently serves as the Chief Scientific Officer in addition to his position within the University.

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NMR and FBLD: From Fragment Screening of GPCRs to Rapid Structure Elucidation

Tuesday, 13 March 2012 at 11:15

Add to Calendar ▼2012-03-13 11:15:002012-03-13 12:15:00Europe/LondonNMR and FBLD: From Fragment Screening of GPCRs to Rapid Structure Elucidation

The strengths of NMR can be brought to bear on multiple aspects of FBLD. Two examples include finding novel ligands for GPCRs and elucidating structures of target-fragment complexes. My lecture will present case studies illustrating each of these areas and how they can be integrated into a single, efficient process to support FBDD efforts

Add to Calendar ▼2012-03-13 00:00:002012-03-14 00:00:00Europe/LondonFragment Based Lead