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SELECTBIO Conferences The Space Summit 2019

Alan Grodzinsky's Biography

Alan Grodzinsky, Professor of Biological, Electrical and Mechanical Engineering, Director of the MIT Center for Biomedical Engineering, Massachusetts Institute of Technology (MIT)

Alan Grodzinsky is the Director of MIT's Center for Biomedical Engineering, and is Professor of Biological, Electrical and Mechanical Engineering in the Departments of Biological Engineering, Electrical Engineering and Computer Science and Mechanical Engineering at MIT. His research interests include Osteoarthritis and the degeneration and repair of cartilage, drug delivery for Osteoarthritis, cellular mechanotransduction and molecular nano-mechanics. He has published over 320 refereed journal articles and reviews in these fields of research. He co-developed two required core graduate courses in the Biological Engineering at MIT and published a textbook related to these subjects on “Fields, Forces and Flows in Biological Systems” (Garland Science, 2011). He was elected Founding Fellow of the American Institute of Medical and Biological Engineering and is past Chair of the Gordon Research Conference on Musculoskeletal Biology and Bioengineering. He is past President of the Orthopaedic Research Society and the International Cartilage Repair Society. He was on the Editorial Boards of Journal of Orthopaedic Research, Polymer Networks and Gels, Arthritis and Rheumatology, and is now on the boards of Osteoarthritis and Cartilage and Biophysical Journal. He received the NIH MERIT Award for research on Cartilage, and other awards including the Melville Medal of the ASME, the Kappa Delta Prize of the American Academy of Orthopaedic Surgeons, and the Borelli Award of the American Society of Biomechanics. He has consulted for numerous industrial and academic institutions, and to federal agencies including the NIH, NSF, FDA, and the Department of Justice, and has received the Honorary Doctorate from the University of Montreal.

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Human Cartilage-Bone-Synovium Chip to Study Post-Traumatic Osteoarthritis Pathogenesis and Treatment on Earth and in Space

Tuesday, 15 October 2019 at 13:30

Add to Calendar ▼2019-10-15 13:30:002019-10-15 14:30:00Europe/LondonHuman Cartilage-Bone-Synovium Chip to Study Post-Traumatic Osteoarthritis Pathogenesis and Treatment on Earth and in SpaceThe Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

Acute joint injuries from sports, exercise or accident-related trauma often progress to post-traumatic Osteoarthritis (PTOA), comprising ~12% of all OA cases. Such joint injuries can cause mechanical damage to cartilage combined with an inflammatory response associated with the synovial lining of the joint capsule. Together, these events lead to cartilage and subchondral bone pathologies including cell death, tissue degradation, neo-angiogenesis, osteophyte and cyst formation and synovial fibrosis. Astronauts are known to sustain a higher rate of exercise-related joint injuries, during their mission period. Since PTOA commonly affects young and otherwise healthy individuals, knee replacement is not a desirable option. Acknowledging the urgent need to identify disease-modifying therapeutics to ameliorate degenerative evolution of OA/PTOA, we carried out this study to (1) simulate aspects of acute joint injury biology on earth and in space using a human Cartilage-Bone-Synovium coculture model (CBS-MPS), (2) to investigate the potential of selected therapeutics to reduce cell death and tissue degradation, and (3) to utilize the Techshot Multi-Use Variable-g Platform (MVP) to study PTOA-related pathogenesis and management on the ISS.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,