Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Organ-on-a-Chip 2020

Roger Kamm's Biography

Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)

Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). Kamm currently directs the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal (American Society of Mechanical Engineering) and the 2015 recipient of the Huiskes Medal (European Society of Biomechanics), both for lifetime achievements, and is the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010. Kamm is co-founder of two companies, Cardiovascular Technologies and AIM Biotech, a manufacturer of microfluidic systems for 3D culture.

Roger Kamm Image

Metastasis on a Chip: Effects of Intravascular and Transendothelial Flow

Tuesday, 29 September 2020 at 14:00

Add to Calendar ▼2020-09-29 14:00:002020-09-29 15:00:00Europe/LondonMetastasis on a Chip: Effects of Intravascular and Transendothelial FlowOrgan-on-a-Chip 2020 in Virtual ConferenceVirtual

Circulating tumor cells (CTC) experience a hostile environment due circulating immune cells and the forces combined with vascular shear stress and pressure gradients.  In this study, we examine flow effects on CTC adhesion, migration and transendothelial migration.  Many CTCs fail to survive the voyage from the primary tumor to the metastatic site, and die before they can initiate a new tumor.  Others not only survive, but enter into the tissue where some fraction proliferate and spread.  We studied the effects of vascular flows, both intravascular (IVF) and transendothelial (TEF) on tumor cell adhesion, migration and transendothelial migration with the goal of better understanding how flow either promotes or impedes metastasis.  Our results show that CTCs migrate or are dragged in the direction of flow prior to trans-endothelial migration.  We also observe enhanced potential for TEM due to IVF.  TEF, on the other hand, has little effect on either migration along the luminal surface of the endothelium or the propensity to undergo trans-endothelial migration, but hastens the process once initiated.  Moreover, TEF increased the migration speed of tumor cells post-extravasation, and caused the cells to remain close to the outer endothelial surface. In summary, both types of flow tend to promote a pro-metastatic phenotype.

Add to Calendar ▼2020-09-28 00:00:002020-09-30 00:00:00Europe/LondonOrgan-on-a-Chip 2020Organ-on-a-Chip 2020 in Virtual ConferenceVirtual