Korea Advanced Institute of Science and Technology
Chulhee Choi is Professor of Department of Bio and Brain Engineering and a chair of Optical Bioimaging Center at KAIST in South Korea. In addition, he is a scientific founder and CEO of Cellex Life Sciences Incorporated, a company dedicated for development of exosome-based protein therapeutics. His group has been studying cell signaling involved in cell death and proliferation in inflammatory conditions and various malignant cancers. Dr. Choi’s group has also focused on development of novel biomedical imaging tools such as dynamic ICG fluorescence imaging for deep tissue perfusion and novel optical technology using femtosecond ultrashort pulsed lasers for modulation of cellular functions. Recently, his team has demonstrated that exosome engineering can be applied for intracellular delivery of bioactive proteins with therapeutic potentials. His group is now pursuing research and development for clinically available exosome-based therapeutics. He is a graduate of Yonsei University College of Medicine, where he received his MD and PhD.
Exosome Engineering for Protein Delivery Via Optogenetic Approach
Tuesday, 20 June 2017 at 09:00
Add to Calendar ▼2017-06-20 09:00:002017-06-20 10:00:00Europe/LondonExosome Engineering for Protein Delivery Via Optogenetic ApproachExosomes and Liquid Biopsies Asia 2017 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com
In this presentation, an opto-genetically engineered exosome system, named ‘exosomes for protein loading via optically reversible protein–protein interaction” (EXPLOR) that can deliver soluble proteins into the cytosol via controlled, reversible protein–protein interactions (PPI) will be introduced. By integrating a reversible PPI module controlled by blue light with the endogenous process of exosome biogenesis, cargo proteins can be loaded into newly generated exosomes. Treatment with protein-loaded EXPLORs was shown to significantly increase intracellular levels of cargo proteins and their function in recipient cells in both a time- and dose-dependent manner. Previously, it has been shown to delivery mCherry, Cre enzyme, Bax, and Super repressor I?B proteins as functional proteins in the target cells and in vivo. In this presentation, the results for follow-up studies will also be discussed.
Add to Calendar ▼2017-06-19 00:00:002017-06-20 00:00:00Europe/LondonExosomes and Liquid Biopsies Asia 2017Exosomes and Liquid Biopsies Asia 2017 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com