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SELECTBIO Conferences Tissue Engineering

Joseph Bonventre's Biography

Joseph Bonventre, Samuel A. Levine Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School

I am Chief of the Renal Division and Chief of the Bioengineering Division at Brigham and Women’s Hospital, Past-President of the American Society of Nephrology. I have a long-standing interest in various aspects of cellular injury and adaptive and maladaptive repair mechanisms in the kidney with a special emphasis on the role of inflammation, biomarkers and stem cells. We have a great deal of experience with various models of AKI and chronic kidney disease. Our work has been cited more than 44,000 times and my citation h-index index is 110. I have received two MERIT awards from NIH and serve on the NIH NIDDK Advisory Council.

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Directed Differentiation of Human Stem Cells to Kidney Organoids and Disease Modeling

Thursday, 17 March 2016 at 17:30

Add to Calendar ▼2016-03-17 17:30:002016-03-17 18:30:00Europe/LondonDirected Differentiation of Human Stem Cells to Kidney Organoids and Disease

I will discuss recent advances in the directed differentiation of human ES cells and IPS cells into nephron progenitors and then kidney organoids.  The efficiency with which nephron progenitor cells are generated is 80-90%. The kidney organoids are characterized by multi-segmented structures with characteristics of podocytes, proximal tubules, loop of Henle, and distal tubules. The tubular structures in the organoids express many transporters that are characteristic of mature nephrons.  The organoids can be used for modeling a variety of both genetic and non-genetic disease processes.

Add to Calendar ▼2016-03-17 00:00:002016-03-18 00:00:00Europe/LondonTissue