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SELECTBIO Conferences Liquid Biopsies and Minimally-Invasive Diagnostics 2017

Ian Papautsky's Biography



Ian Papautsky, Richard and Loan Hill Professor of Bioengineering, Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics, University of Illinois at Chicago

Ian Papautsky is the Richard and Loan Hill Professor in the biomedical engineering department. His lab focuses on using microfluidics to innovate blood analysis. Papautsky was one of the pioneers of the inertial microfluidics technology for label-free isolation and analysis of rare cells. His recent work has focused on applying this approach to the fractionation of blood, as well as capture and subsequent molecular profile analysis of circulating tumor cells for liquid biopsy. Papautsky is also co-director of the National Science Foundation Center for Advanced Design and Manufacturing of Integrated Microfluidics, an industry-university collaborative research center that fosters interactions between academics and businesses in the areas of medical devices, pharmacology, and precision agriculture. Papautsky joined the University of Illinois Chicago in 2016. He has been recognized with many awards and honors, including Ohio Bioscience 30 in Their 30s. He is fellow of the AIMBE and the RSC.

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Isolation of Cells from Undiluted Whole Blood Using Inertial Microfluidics

Thursday, 5 October 2017 at 14:00

Add to Calendar ▼2017-10-05 14:00:002017-10-05 15:00:00Europe/LondonIsolation of Cells from Undiluted Whole Blood Using Inertial MicrofluidicsLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Inertial microfluidics is receiving considerable attention for applications in cell separation and liquid biopsy.  However, while these devices have been widely explored for cell separation, sample dilution is necessary. Here, we report on a novel approach to achieve cell separation directly from unprocessed whole blood based solely on cell size.  The separation is achieved through coupling of inertial effects with shear-induced diffusion. Our results from high-speed imaging reveal that focusing of larger cells near the channel centerline is possible, leading to easy separation. Whole blood spiked with fluorescently labeled beads and cells was used to demonstrate the separation principle and its performance without any sample pretreatment. Results confirm the high quality of performance in terms of efficiency (>90%) and RBC rejection rate (>96%).  This work also successfully demonstrates the use of an inertial microfluidic device as a laboratory tool for sorting target cells from undiluted whole blood.


Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2017Liquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com