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SELECTBIO Conferences Exosomes and Extracellular Vesicles (EV): Research, Diagnostics and Therapeutics Opportunities

Andrew Hoffman's Biography



Andrew Hoffman, Professor, Director -- Regenerative Medicine Laboratory, Tufts University

Dr. Andy Hoffman is a large animal internist with long-standing interest in regenerative medicine and translational potential of veterinary disease models to improve human and animal health. His lab focuses on the functional relevance of exosomal miR derived from biofluids (e.g. blood, CSF, saliva) to disease pathogenesis. Are exosomes in biofluids directly involved in the initiation or propagation of disease or bystanders which also have strong biomarker potential? His unique approach is to study these phenomena in companion animal disease models which strikingly resemble human conditions. Models that he works with include congestive heart failure secondary to mitral valve prolapse, arrythmogenic right ventricular cardiomyopathy, atopic dermatitis, Crohn’s fistulitis, spinal disc herniation, and cardiac arrest, updated on Dr. Hoffman’s webpage: http://sites.tufts.edu/vetclinicaltrials/regenerative-medicine-stem-cell-trials/.

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Companion Animal Studies Advance Understanding of Disease-Relevant Circulating Exosome specific miR Signatures

Tuesday, 21 March 2017 at 15:30

Add to Calendar ▼2017-03-21 15:30:002017-03-21 16:30:00Europe/LondonCompanion Animal Studies Advance Understanding of Disease-Relevant Circulating Exosome specific miR SignaturesSELECTBIOenquiries@selectbiosciences.com

Companion animal disease models strongly resemble human diseases and biofluids from these animals are readily accessible sources of exosomes for longitudinal studies.  We present an analysis of miRNomic data from circulating exosomes derived from dogs with naturally occurring heart diseases also found in humans (mitral valve disease, arrythmogenic right ventricular cardiomyopathy).   Target mRNA and gene networks underpinning miR-target interactions were identified in silico for candidate miR.   The process of functional, biological, and clinical characterization of circulating exosome specific miR in companion animals will be discussed.


Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonExosomes and Extracellular Vesicles (EV): Research, Diagnostics and Therapeutics OpportunitiesSELECTBIOenquiries@selectbiosciences.com