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SELECTBIO Conferences NGS, SCA, Mass Spec: The Road to Diagnostics

Benjamin Yellen's Biography



Benjamin Yellen, Associate Professor, Biomedical Engineering, Mechanical Engineering and Materials Science, Duke University

Benjamin Yellen is an Associate Professor at Duke University in the Department of Mechanical Engineering and Materials Science, with a secondary appointment in the Biomedical Engineering Department. His research interests lay at the intersection of electromagnetic field theory, nonlinear dynamics & controls, and colloid & surface science, for applications in materials science and biomedical devices. Yellen has more than 50 publications, many in high impact journals, including Nature and PNAS, and he has received funding from NSF, NIH, DARPA, and other non-governmental agencies to support his research. In 2014, Yellen was the recipient of the CNIHR (Creative and Novel Ideals for HIV Research) award, which brings scientists without prior HIV research experience and fresh ideas into the field. Towards this end, Yellen has initiated collaboration with colleagues at the medicals schools of Duke and UNC to apply magnetic control mechanisms for organizing large arrays of single cells on chip. The goal of these manipulations is to uncover kinetic epigenetic relationships in the maintenance of latency in HIV-1 infected CD4 single cells, and in the eradication of latent cell reservoirs through the real-time analysis of cytolytic interactions between CD4 and CD8 single cell pairs.

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Single Cell Random Access Memory

Tuesday, 29 September 2015 at 17:00

Add to Calendar ▼2015-09-29 17:00:002015-09-29 18:00:00Europe/LondonSingle Cell Random Access MemoryNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, we have recently demonstrated a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.  The presentation will focus on our recent progress on optimizing these integrated circuits to manipulate magnetically labeled CD4+ T cells, including recent data on single cell switches, cell velocities on chip, as well as the ability of non-fouling surface coatings to resist non-specific adhesion between the cells and chip surface.


Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonNGS, SCA, Mass Spec: The Road to DiagnosticsNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com