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SELECTBIO Conferences Cell & Gene Therapy Asia 2019

Shoji Takeuchi's Biography

Shoji Takeuchi, Professor, Center For International Research on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science, The University of Tokyo

Shoji Takeuchi received the B.E, M.E., and Dr. Eng. degrees in mechanical engineering from the University of Tokyo, Tokyo, Japan, in 1995, 1997, and 2000, respectively. He is currently a Professor in the Center for International Research on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science (IIS), University of Tokyo. Since 2008, he is a director of Collaborative Research Center for Bio/Nano Hybrid Process at IIS. His current research interests include membrane protein chips, bottom-up tissue engineering and biohybrid MEMS. He received several awards including Young Scientists' Prize, the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology in 2008, the JSPS prize from the Japan Society for the Promotion of Science in 2010.

Shoji Takeuchi Image

Cell Fiber Technology for Cell Therapy

Monday, 11 November 2019 at 16:10

Add to Calendar ▼2019-11-11 16:10:002019-11-11 17:10:00Europe/LondonCell Fiber Technology for Cell TherapyCell and Gene Therapy Asia 2019 in Kobe, JapanKobe,

The cell fiber was produced in a double coaxial laminar flow microfluidic device. The core stream of cells suspended in ECM sol and the shell stream of sodium alginate sol form a core-shell laminar co-flow in the device; the flow of Na-alginate sol becomes a gel at the point where it merges with the sheath stream of calcium chloride solution.  As a result, a Ca-alginate shell with the cells and ECM sol in the core can be continuously generated on a meter-length scale.  The three-dimensionally cultured cells in the fiber show excellent intrinsic functions. When with myocytes, endothelial, and nerve cells, they showed the contractile motion of the myocyte cell fiber, the tube formation of the endothelial cell fibers and the synaptic connections of the nerve cell fiber, respectively.  By using microfluidic handling, higher-order assembly of fiber-shaped 3D cellular constructs can be performed; in particular, mechanical weaving of cell fibers with our lab-made microfluidic weaving machine provides a woven "cell fabric" composed of three different cell fibers. As the practical application, the fiber encapsulating beta-cells is used for the implantation of diabetic mice, and succeeded in normalizing the blood glucose level.

Add to Calendar ▼2019-11-11 00:00:002019-11-12 00:00:00Europe/LondonCell and Gene Therapy Asia 2019Cell and Gene Therapy Asia 2019 in Kobe, JapanKobe,