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SELECTBIO Conferences Multi-Cellular Engineered Living Systems Summit

Linda Griffith's Biography



Linda Griffith, Professor, Massachusetts Institute of Technology (MIT)

Linda G. Griffith, PhD, is the School of Engineering Teaching Innovation Professor of Biological and Mechanical Engineering and MacVicar Fellow at MIT, where she directs the Center for Gynepathology Research and the Human Physiome on a Chip Project supported by the DARPA/NIH-funded Microphysiological Systems Program. Dr. Griffith received a Bachelor's Degree from Georgia Tech and a PhD degree from the University of California at Berkeley, both in chemical engineering. Dr. Griffith’s research is in the field of regenerative medicine and tissue engineering. Her laboratory, in collaboration with J. Upton and C. Vacanti, was the first to combine a degradable scaffold with donor cells to create tissue-engineered cartilage in the shape of a human ear. The 3D Printing Process she co-invented for creation of complex scaffolds has been commercialized for manufacture of FDA-approved scaffolds for bone regeneration. She is also a pioneer in devising ways to control nano-scale stimulation of cells by molecular cues, and in creation of 3D tissue models for drug development. The 3D perfused “LiverChip” liver tissue culture technology has been commercialized for applications in drug development. A current focus is integration of tissue engineering with systems biology, with an emphasis on endometriosis and other women’s reproductive diseases. She is a member of the National Academy of Engineering and the recipient of a MacArthur Foundation Fellowship, the Popular Science Brilliant 10 Award, NSF Presidential Young Investigator Award, the MIT Class of 1960 Teaching Innovation Award, Radcliffe Fellow and several awards from professional societies. She has served as a member of the Advisory Councils for the National Institute for Dental and Craniofacial Research and the National Institute of Arthritis, Musculoskeletal and Skin Diseases at NIH. As chair of the Undergraduate Curriculum Committee for Biological Engineering at MIT, she led development of the new Biological Engineering SB degree program, which was approved in 2005 as MIT’s first new undergraduate major in 39 years.

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Engineering Mucosal Barriers: From Organoids to Organs–on–Chips

Wednesday, 25 March 2020 at 08:45

Add to Calendar ▼2020-03-25 08:45:002020-03-25 09:45:00Europe/LondonEngineering Mucosal Barriers: From Organoids to Organs–on–ChipsMulti-Cellular Engineered Living Systems Summit in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com

Mucosal barriers are the gateways to all internal organs, serving to transport oxygen, nutrients, and waste and at the same time performing enormous feats of protection against infection and other hazardous insults.  The explosion of interest in the human microbiome – especially but not only that in the gut – has driven new interest in building human mucosal barrier models. This talk will highlight three related themes: (i) engineering synthetic microenvironments to expand primary adult epithelial organoids and induce morphogenesis into mucosal barriers (ii) engineering microfluidic devices to create microbial-mucosal interfaces that enable chronic co-culture of the most super strict anaerobes such as Faecalibacterium prausnitzii with a colon mucosal barrier and (iii) interconnection of mucosal barriers with other tissues in systemic circuits to illuminate the role of gut-derived bacterial metabolites on function of other organ systems.  Examples will emphasize how these approaches can be used to model chronic inflammatory diseases.


Add to Calendar ▼2020-03-25 00:00:002020-03-25 00:00:00Europe/LondonMulti-Cellular Engineered Living Systems SummitMulti-Cellular Engineered Living Systems Summit in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com