Linda Griffith,
Professor,
Massachusetts Institute of Technology (MIT)
Linda G. Griffith, PhD, is the School of Engineering Teaching Innovation Professor of Biological and Mechanical Engineering and MacVicar Fellow at MIT, where she directs the Center for Gynepathology Research and the Human Physiome on a Chip Project supported by the DARPA/NIH-funded Microphysiological Systems Program. Dr. Griffith received a Bachelor's Degree from Georgia Tech and a PhD degree from the University of California at Berkeley, both in chemical engineering. Dr. Griffith’s research is in the field of regenerative medicine and tissue engineering. Her laboratory, in collaboration with J. Upton and C. Vacanti, was the first to combine a degradable scaffold with donor cells to create tissue-engineered cartilage in the shape of a human ear. The 3D Printing Process she co-invented for creation of complex scaffolds has been commercialized for manufacture of FDA-approved scaffolds for bone regeneration. She is also a pioneer in devising ways to control nano-scale stimulation of cells by molecular cues, and in creation of 3D tissue models for drug development. The 3D perfused “LiverChip” liver tissue culture technology has been commercialized for applications in drug development. A current focus is integration of tissue engineering with systems biology, with an emphasis on endometriosis and other women’s reproductive diseases. She is a member of the National Academy of Engineering and the recipient of a MacArthur Foundation Fellowship, the Popular Science Brilliant 10 Award, NSF Presidential Young Investigator Award, the MIT Class of 1960 Teaching Innovation Award, Radcliffe Fellow and several awards from professional societies. She has served as a member of the Advisory Councils for the National Institute for Dental and Craniofacial Research and the National Institute of Arthritis, Musculoskeletal and Skin Diseases at NIH. As chair of the Undergraduate Curriculum Committee for Biological Engineering at MIT, she led development of the new Biological Engineering SB degree program, which was approved in 2005 as MIT’s first new undergraduate major in 39 years.
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Multi-MPS Interactions for Chronic Inflammatory Disease: A Scaling ChallengeThursday, 4 October 2018 at 12:00 The pioneering work of Shuler and colleagues over 20 year ago demonstrated the potential for using interconnected MPS for pharmacology and toxicology applications by showing metabolic conversion of a compound in one MPS and downstream effects on a second MPS. As the role of immunological contributions to drug safety have become more appreciated, the need for more complex immunologically-competent MPS has grown. This has driven development of more complex MPS that are also potentially valuable for modeling inflammatory diseases. This talk will address technical challenges in modeling complex diseases with “organs on chips” approaches include the need for relatively large tissue masses and organ-organ cross talk to capture systemic effects, as well as new ways of thinking about scaling to capture multiple different functionalities from drug clearance to cytokine signaling crosstalk. An example of how gut-liver interactions can be parsed at these levels will be featured, along with new approaches for culturing complex 3D tissues with synthetic extracellular matrix and higher-order multi-organ interactions involving immunology.
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