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SELECTBIO Conferences Drug Discovery Automation - HCS & Cell Based Assays

Carsten Grotzinger's Biography



Carsten Grotzinger, Group Leader/Head, Charite University Medicine Berlin

Dr Carsten Grötzinger is a group leader at the Charité - Universitätsmedizin Berlin. He graduated from Humboldt University in Berlin with a Diploma in Biochemistry and Molecular Biology. After his PhD work on Coronavirus replication at the University of Würzburg he joined the Charité in Berlin as a postdoc focusing on cell adhesion, tumor markers and somatostatin-mediated optical tumor imaging. His research group has a key interest in developing peptide-derived GPCR ligands for targeting tumors in the gastrointestinal tract. Supported by a grant from the German ministry of education and research, Carsten recently initiated an applied research program involving aspects of both target validation and ligand optimization as well as preclinical optical imaging. His research group at the Campus Virchow-Klinikum is affiliated with the Gastroenterology Department and the Molecular Cancer Research Center of the Charité.

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Identification of Highly Potent, Short and Stable Chemerin Analogs using High-Content Analysis and Other Cell-Based Assays

Wednesday, 30 May 2012 at 16:00

Add to Calendar ▼2012-05-30 16:00:002012-05-30 17:00:00Europe/LondonIdentification of Highly Potent, Short and Stable Chemerin Analogs using High-Content Analysis and Other Cell-Based AssaysSELECTBIOenquiries@selectbiosciences.com

CMKLR1 is a GPCR overexpressed in squamous cell carcinomas of the esophagus. We have advanced the wild-type C-terminal nonamer peptide of its ligand chemerin into highly stabilized analogues that retain both high affinity and receptor activation. Coupling optimized peptide variants to fluorescent dyes and chelators via different linkers enabled us to generate contrast for tumor imaging.


Add to Calendar ▼2012-05-30 00:00:002012-05-31 00:00:00Europe/LondonDrug Discovery Automation - HCS and Cell Based AssaysSELECTBIOenquiries@selectbiosciences.com