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SELECTBIO Conferences Targeting Protein-Protein Interactions

Ian Hardcastle's Biography



Ian Hardcastle, Lecturer, Newcastle University

Ian Hardcastle gained his PhD in Synthetic Organic Chemistry in 1990 at Manchester University. From there he joined Prof. M Jarman’s team as a post-doctoral fellow at The Institute of Cancer Research, Sutton working on the medicinal chemistry of antiestrogens, CYP17A1 inhibitors including the discovery of abiraterone, and signalling targets in cancer. In 1999 he joined the CR UK funded drug discovery team at Newcastle University as Lecturer in Medicinal Chemistry.

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Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors

Tuesday, 19 March 2013 at 11:45

Add to Calendar ▼2013-03-19 11:45:002013-03-19 12:45:00Europe/LondonApproaches to the Discovery of Small-molecule MDM2-p53 InhibitorsSELECTBIOenquiries@selectbiosciences.com

The MDM2-p53 protein-protein interaction is a well validated and tractable drug target. Potent small-molecule inhibitors including the Nutlin series have been reported. The approaches for the discovery of MDM2-p53 inhibitors based on the isoindolinone, and pyrrole scaffold will be described.


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonTargeting Protein-Protein InteractionsSELECTBIOenquiries@selectbiosciences.com