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SELECTBIO Conferences Point-of-Care Diagnostics and Biosensors 2021

Brian Cunningham's Biography

Brian Cunningham, Professor and Intel Alumni Endowed Chair, University of Illinois at Urbana-Champaign

Prof. Cunningham has been a faculty member in the department of Electrical and Computer Engineering and the department Bioengineering at the University of Illinois at Urbana-Champaign since 2004, following a 15-year career in Industry. Prof. Cunningham’s technical focus is the utilization of photonics for biosensing in applications that include life science research, diagnostics, environmental monitoring, and pharmaceutical screening. He has over 90 issued US patents and over 200 peer reviewed journal publications. He is a Fellow of NAI, IEEE, Optica, RSC, AAAS, and AIMBE. He serves as the Director of the Center for Genomic Diagnostics at the Woese Institute for Genomic Biology, and as a Program Leader for the Cancer Center at Illinois on the topic of Cancer Measurement Technology and Data Science. In 2023, his technical contributions were recognized by Optica by the Michael S. Feld Biophotonics Award.

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Digital Resolution Liquid Biopsy at the Point of Care

Tuesday, 14 December 2021 at 16:00

Add to Calendar ▼2021-12-14 16:00:002021-12-14 17:00:00Europe/LondonDigital Resolution Liquid Biopsy at the Point of CarePoint-of-Care Diagnostics and Biosensors 2021 in Coronado Island, CaliforniaCoronado Island,

As clinicians seek improved methods for tailoring medical treatment to the specific needs of individual patients, research is revealing that an important reservoir of information relevant to gene expression, mutation burden, immune response, and pathogen exposure is available in the profile of biomolecules present in bodily fluids.  Because samples can be obtained non-invasively, so-called “liquid biopsies” enable testing for disease onset, measuring the effects of therapy, and monitoring for disease recurrence after treatment. As liquid biopsy approaches become more routine, they also offer the promise for monitoring metrics for health/wellness, quantifying the effects of nutritional regimens, and determining the effects of exposure to a variety of environments.  Practical realization of this goal is challenging due to the extremely low concentration of relevant biomolecules within complex fluids, and the desire to accurately quantify concentrations that can vary over several orders of magnitude.  For widespread adoption, it is important to develop simple assay methods with inexpensive instruments that can potentially be used at the point of care. This talk will describe ultrasensitive and highly selective biomolecular detection approaches developed by our team that achieve digital resolution detection of nucleic acid and protein biomarkers with rapid, single-step, room temperature workflows that do not require enzymatic amplification.  Utilizing photonic metamaterials in combination with novel biochemistry methods for biomarker recognition, we envision liquid biopsy approaches that can provide quantitative assessments for multiplexed targets in point of care settings.

Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonPoint-of-Care Diagnostics and Biosensors 2021Point-of-Care Diagnostics and Biosensors 2021 in Coronado Island, CaliforniaCoronado Island,