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SELECTBIO Conferences Biofluid Biopsies and Companion Diagnostics 2014

Michael Heller's Biography

Michael Heller, Professor, University of California San Diego

Michael J. Heller received his Ph.D. in Biochemistry from Colorado State University in 1973. He was an NIH Postdoctoral Fellow at Northwestern University from 1973 to 1976. Dr. Heller was supervisor of the DNA Technology Group at Amoco Corporation (Standard Oil Indiana) from 1976 to 1984. During that period he carried out bioengineering work on chemiluminescent, fluorescent and FRET DNA probe diagnostics and recombinant DNA engineering work on plants, algae and photosynthetic bacteria for energy and chemical production. He also oversaw the Amoco sponsored research projects (>$5 million) at Cetus Corporation on related recombinant DNA work for energy and chemical production and thermophilic enzymes. Dr. Heller was Director of Molecular Biology at Molecular Biosystems, Inc., from 1984 to 1987. He was a co-founder of Integrated DNA Technologies, and served as President and Chief Operating Officer from 1987 to 1989. He was a co-found of Nanotronics and Nanogen, and served as the Chief Technical Officer from 1993 to 2001. Nanogen carried out the successful development and commercialization of microelectronic DNA array technology for clinical genotyping applications. Dr. Heller is now a Professor in the Departments of Nanoengineering and Bioengineering at the University California San Diego. He has also recently co-founded a new company called Biological Dynamics which will be developing new cancer diagnostic technology. Dr. Heller has extensive industrial experience in biotechnology, biomedical and clinical diagnostic devices and nanotechnology; with particular expertise in the areas of DNA probe diagnostics, DNA synthesis, fluorescent-based detection technologies and electric field assisted self-assembly of DNA nanocomponents. Dr. Heller has a respectable publication record, and has been an invited speaker to a large number of scientific conferences and meetings related to DNA microarrays, biosensors, lab-on-a-chip devices, bio-MEMS and nanotechnology. He has over 50 issued US patents related to microelectronic chips, microarrays and integrated devices for DNA hybridization, miniaturized sample to answer diagnostic devices, biosensors, genomics, proteomics, nanotechnology and nanofabrication, nano-based DNA optical storage and for fluorescent energy transfer in DNA nanostructures. Dr. Heller has been a panel member for the White House (OSTP) National Nanotechnology Initiative 1999/2000; the NAS (NAE) Review of National Nanotechnology Initiative 2001-2002; the NAS(NAE) – Engineer for the 2020 - 2001/2002; and has also been involved in a number of NSF Nanotechnology Workshops.

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Rapid Isolation and Detection of DNA/RNA Biomarkers from Blood and Plasma “Key to Liquid Biopsy Diagnostics”

Monday, 27 October 2014 at 16:45

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The analysis of circulating cell free (ccf) DNA and RNA continues to become more widely used for cancer diagnostics and management. The parallel development of new methods that allow rapid isolation directly from small amounts of blood or plasma will also be necessary to advance liquid biopsy point of care (POC) diagnostic applications. We have now demonstrated a dielectrophoretic (DEP) based approach that allows cfc-DNA and RNA biomarkers from chronic lymphocytic leukemia (CLL) patients to be isolated in about 10 minutes directly from a small volume (25ul) of patient whole blood or plasma.

Add to Calendar ▼2014-10-27 00:00:002014-10-28 00:00:00Europe/LondonBiofluid Biopsies and Companion Diagnostics 2014Biofluid Biopsies and Companion Diagnostics 2014 in San Diego, California, USASan Diego, California,