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SELECTBIO Conferences Lab-on-a-Chip & Microfluidics World Congress 2019

Michael Heller's Biography



Michael Heller, Distinguished Scientist - Knight Cancer Institute at Oregon Health & Science University (OHSU), Center for Cancer Early Detection and Research (CEDAR); Professor, University of California-San Diego

Michael J. Heller received his Ph.D. in Biochemistry from Colorado State University in 1973. He was an NIH Postdoctoral Fellow at Northwestern University from 1973 to 1976. From 1976 to 1984 he was supervisor of the DNA Technology Group at Amoco Corporation (Standard Oil Indiana) During that time he carried out early bioengineering and recombinant DNA work on plants, algae and photosynthetic bacteria for energy and chemical production, and he developed some of the first fluorescent resonant energy transfer (FRET) and chemiluminescent oligonucleotide probes for DNA hybridization analysis. He also oversaw Amoco’s sponsored energy and chemical research work at Cetus Corporation, which included the cloning of thermophilic enzymes. Dr. Heller was the Director of Molecular Biology at Molecular Biosystems, Inc., from 1984 to 1987. He was a co-founder of Integrated DNA Technologies, and served as President and Chief Operating Officer from 1987 to 1989. He was a co-found of Nanogen, and served as the Chief Technical Officer from 1993 to 2001. Nanogen carried out the successful development and commercialization of electronic DNA microarray technology for clinical diagnostic genotyping applications. Dr. Heller is a Professor (Recall/Emeritus) in the Departments of Nanoengineering and Bioengineering at the University California San Diego. He is also now a Distinguished Scientist at the Oregon Health & Science University (OHSU), Center for Cancer Early Detection and Research (CEDAR), in Portland, Oregon. He has recently co-founded a new company called Biological Dynamics which is developing new sample to answer cancer diagnostics technology, based on the novel dielectrophoretic (DEP) technology developed at his UCSD lab. Dr. Heller has extensive industrial experience in biotechnology, biomedical and molecular diagnostic devices and nanotechnology, with particular expertise in the areas of DNA probe diagnostics, DC and AC electrokinetic devices, DNA synthesis, FRET/fluorescent-based detection technologies and electric field assisted self-assembly of DNA nanocomponents. Dr. Heller has a respectable publication record, and has been an invited speaker to a large number of scientific conferences, which now include recent meetings on cell free nucleic acid and exosome biomarkers for cancer detection and molecular diagnostics. He also has over 55 issued US patents in the molecular diagnostics, biotechnology and nanotechnology areas.

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Sample to Answer Device for Multi-Omic Biomarker Analysis of Cancer Patient Blood Samples

Tuesday, 8 October 2019 at 10:00

Add to Calendar ▼SELECTBIOenquiries@selectbiosciences.com

Multi-Omic approaches for different biomarkers is becoming a viable strategy for liquid biopsy diagnostics and early cancer detection. Using new electrokinetic devices (ACE chip, Biological Dynamics, San Diego, CA) now allow sample to answer Multi-Omic analysis of exosome and extracellular vesicle (EV) biomarkers as well as cell free (cf) DNA and RNA from the “same” 20-50 µL sample of blood, plasma or serum. Fluorescent detection of the cf-DNA and RNA, and immunostaining for exosome/EV protein biomarkers can be rapidly carried out directly on-chip. Subsequently, cf-DNA and exosome/EV entrapped RNA can be eluted from the ACE chip, whereupon dd-PCR, PCR and sequencing analysis is conducted to identify cancer-related point mutations. We were able to show correlation of immunofluorescent detection of exosome/EV glypican-1 and cf-DNA KRAS mutations determined by digital PCR and Sanger Sequencing for a number of pancreatic patient samples. This provides further advancement towards integrating multi-omic analysis as a single, on-chip platform, with an ultimate goal of providing seamless sample-to-answer point-of-care liquid biopsy diagnostics and therapy monitoring from a small sample of patient blood.


Add to Calendar ▼2019-10-07 00:00:002019-10-09 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics World Congress 2019Lab-on-a-Chip and Microfluidics World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com