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SELECTBIO Conferences Targeting Protein-Protein Interactions

Volkhard Helms's Biography



Volkhard Helms, Chair of Computational Biology, Universitat des Saarlandes

Volkhard Helms studied physics at the Universities of Freiburg and Munich. He did his PhD research at EMBL Heidelberg, working in the group of Dr. Rebecca Wade on cytochrome P450s, and obtained a PhD in physics in 1996. As post-doctoral fellow at UC San Diego with Prof.J.Andrew McCammon he used computer simulations to study ligand recognition by protein kinases and the photophysics of the green fluorescent protein. From 1998-2003, Volkhard Helms led a junior research group at the Max Planck Institute for Biophysics in Frankfurt, where his group studied proton translocation events and the mechanistics of protein-protein interactions. He obtained his habilitation in physics in 2002. In 2003, he was appointed professor for bioinformatics at the Center for Bioinformatics of Saarland University in Saarbr├╝cken. In 2001, he received the EMBO young investigator award. His current research focuses on biomolecular interactions involving proteins and DNA, predicting structural and functional features of transmembrane proteins, epigenetic control of cell differentiation, and antibiotic resistance

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Druggability of Dynamic Protein-protein Interfaces

Wednesday, 20 March 2013 at 11:45

Add to Calendar ▼2013-03-20 11:45:002013-03-20 12:45:00Europe/LondonDruggability of Dynamic Protein-protein Interfaces SELECTBIOenquiries@selectbiosciences.com

Molecular dynamics simulations of the proteins MDM2, IL-2, Bcl-XL, the XIAP Bir2 domain, and PDK1 identified frequent formation of transition pockets on the protein surfaces. Ligand docking confirmed that these pockets are suitable to bind known ligand molecules.


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonTargeting Protein-Protein InteractionsSELECTBIOenquiries@selectbiosciences.com