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SELECTBIO Conferences ADME & Predictive Toxicology

Thomas Joos's Biography



Thomas Joos, Deputy Managing Director, University of Tuebingen

Dr. Joos joined 1998 the NMI at the University of Tuebingen heading the department of biochemistry. Since 2013 he is the deputy managing director. His research is focused on miniaturized multiplexed immunoassays for biomarker research and diagnostic applications. Dr. Joos studied Biochemistry at the University of Tübingen. He performed his Ph.D. degree in 1985 on integrin-?5 during early embroygenesis of Xenopus laevis in the laboratory of Prof. Peter Hausen at the Max-Planck-Institute of Developmental Biology. Dr. Joos is a member of the editorial board of Drug Discovery Today, Proteomics, Molecular Biotechnology and Expert Review of Proteomics. He is a member of the scientific advisory board of the "Plasma Proteome Institute" Washington, DC, USA, of the “AlbaNova VINN Excellence Centre for Protein Technology (ProNova)” at the Royal Institute of Technology, Stockholm, Sweden, and of Myriad-RBM, Austin, TX, USA.

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Multiplexed Immunoassays for the Analysis of Drug Effects on the Liver and Kidney

Tuesday, 18 February 2014 at 09:00

Add to Calendar ▼2014-02-18 17:15:002014-02-18 18:15:00Europe/LondonRound Table DiscussionADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

For the in depth analysis of drug induced organ injuries miniaturized multiplexed immunoassays are powerful tools. Biomarker qualification and application will be discussed. In addition, our immunoaffinity enrichment procedures combined with a mass spectrometric based readout requiring only a minimal set of antibodies will be presented. This approach enables the accurate quantification of the cytochrome P450 superfamily and a variety of drug transporter. Such assays allow to follow upregulation of these analytes on the protein level after drug treatment.

Round Table Discussion

Tuesday, 18 February 2014 at 17:15

Add to Calendar ▼2014-02-18 17:15:002014-02-18 18:15:00Europe/LondonRound Table DiscussionADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

Key Areas for Discussion:

  • Predicting Human ADME Parameters
  • In-silico: Reliable Predictive Models may Replace Costly Experiments
  • Animal Models Versus Human Cell Culture Assays Biomarkers 
  • How Predictable are Nonclinical Extrapolation Methods? 
  • What are the Downsides to Basing Drug Development Decisions on PK/PD Modeling Predictions? 
  • What is Needed to Enhance the Impact of Modeling Predictions? 

    The discussions will be held in the Exhibition Hall.


Add to Calendar ▼2014-02-18 00:00:002014-02-19 00:00:00Europe/LondonADME and Predictive ToxicologyADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com