Angling Downstream For Next-Generation Hedgehog Pathway AntagonistsTuesday, 22 March 2016 at 14:15 Add to Calendar ▼2016-03-22 14:15:002016-03-22 15:15:00Europe/LondonAngling Downstream For Next-Generation Hedgehog Pathway AntagonistsAcademic Drug Discovery 2016 in Cambridge, UKCambridge, UKSELECTBIOenquiries@selectbiosciences.com Therapeutic strategies for Gli-dependent oncogenesis have primarily focused on Smoothened, a membrane receptor that regulates Gli function. Using high-throughput screens, we have discovered genetic drivers and chemical inhibitors that act downstream of Smoothened to control Gli activity. |