Disease Biology Through Whole Genome RNAi Screening: The SOD1 and TDP-43 ConnectionWednesday, 18 September 2013 at 10:30  Add to Calendar ▼2013-09-18 10:30:002013-09-18 11:30:00Europe/LondonDisease Biology Through Whole Genome RNAi Screening: The SOD1 and TDP-43 ConnectionAcademic Screening Workshop 2013 in Baltimore, MA, USABaltimore, MA, USASELECTBIOenquiries@selectbiosciences.comProteinaceous inclusions in sporadic amyotrophic lateral sclerosis (ALS) contain TAR DNA binding protein (TDP-43), other ubiquitinated proteins but rarely contain superoxide dismutase 1 (SOD1). This has led to the hypothesis that SOD1-linked and sporadic ALS follow independent paths despite common pathophysiology. To understand the link between SOD1 and sporadic ALS a whole genome RNAi screen was carried out to identify modulators of SOD1 expression. Interestingly we identified TDP-43, a protein linked to sporadic ALS in the highest ranked protein network mapped from the hits. TDP-43 negatively regulates SOD1 and this could help explain the oxidative deregulation commonly observed in ALS. |
Add to Calendar ▼2013-09-17 00:00:002013-09-18 00:00:00Europe/LondonAcademic Screening Workshop 2013Academic Screening Workshop 2013 in Baltimore, MA, USABaltimore, MA, USASELECTBIOenquiries@selectbiosciences.com
