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SELECTBIO Conferences Emerging Themes and Technologies in Tissue Engineering and Bioprinting

John Fisher's Biography

John Fisher, Fischell Family Distinguished Professor & Department Chair; Director, NIH Center for Engineering Complex Tissues, University of Maryland

Dr. John P. Fisher is the Fischell Family Distinguished Professor and Department Chair in the Fischell Department of Bioengineering at the University of Maryland. Dr. Fisher is also the Director of the newly established NIH Center for Engineering Complex Tissue (CECT) that aims to create a broad community focusing on 3D printing and bioprinting for regenerative medicine applications. Dr. Fisher completed a B.S. in biomedical and chemical engineering at The Johns Hopkins University (1995), M.S. in chemical engineering at the University of Cincinnati (1998), Ph.D. in bioengineering at Rice University (2003), and postdoctoral fellowship in cartilage biology and engineering at the University of California Davis (2003). As the Director of the Tissue Engineering and Biomaterials Laboratory, Dr. Fisher’s group investigates biomaterials, stem cells, bioprinting, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, and cardiovascular tissues. Initially, the laboratory developed a novel class of biodegradable polymers, based upon an acetal monomer, that result in non-acidic degradation products upon hydrolysis. The laboratory utilized these, and other polymer systems (both natural and synthetic) to create biomimetic environments for cell culture and, critically, demonstrated the relationship between cell microenvironment and endogenous protein signal expression. Subsequent efforts focused on the development of a novel perfusion bioreactor for dynamic cell culture. Most recently, Dr. Fisher’s laboratory has developed strategies for the 3D printing of a variety of tissue engineering biomaterials and scaffolds. Overall, the laboratory has published over 140 articles, book chapters, and proceedings (4900+ citations / 39 h-index) as well as delivered over 285 invited and contributed presentations, while utilizing over $15M in financial support from NIH, NSF, FDA, NIST, DoD, and other institutions. Fisher has advised 8 postdoctoral fellows (3 current), 23 doctoral students (12 current), 6 Master students, and supported the research activities of over 65 undergraduates (8 current). Students in Dr. Fisher’s laboratory have received a number of awards and honors: University of Maryland Undergraduate Researcher of the Year (3), Bioengineering Department Outstanding Graduate Researcher of the Year (2), NSF Graduate Fellows (2), AHA Graduate Fellow (3), NIH Postdoctoral Fellow (1), Fulbright Fellow (2), and TERMIS / Mary Ann Liebert Outstanding Student (1). Fisher has been elected Fellow of both the American Institute for Medical and Biological Engineering (2012) and the Biomedical Engineering Society (2016). Fisher has received the NSF CAREER Award (2005), Arthritis Foundation’s Investigator Award (2006), Outstanding Graduate Alumnus Award from the Department of Bioengineering at Rice University (2007), Engalitcheff Award from the Arthritis Foundation (2008), Next Power Professorship from Tsing Hua University in Taiwan (2015), and a Fulbright Fellowship to study at the National University of Ireland, Galway (2015). At the University of Maryland, Fisher has received the Invention of the Year Award (2006 & 2014), First Place in the Venture Fair Competition (2009 & 2013), Teaching Excellence Award from the Fischell Department of Bioengineering (2011), Graduate Faculty Mentor of the Year Award (2015), and the Outstanding Director of Graduate Studies Award (2015). Fisher is currently the Editor-in-Chief of the journal Tissue Engineering, Part B: Reviews. In addition, Fisher has edited or co-edited 6 monographs in the field of tissue engineering. In 2014, Fisher was the Chair of the Tissue Engineering and Regenerative Medicine International Society– Americas (TERMIS-AM) Chapter Annual Meeting in Washington, DC. In 2014, Fisher was elected Chair of TERMIS-AM, and in 2015 started his term as Chair-Elect of the society.

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Three Dimensional Printing of Biodegradable Cardiovascular Biomaterials

Tuesday, 10 February 2015 at 15:30

Add to Calendar ▼2015-02-10 15:30:002015-02-10 16:30:00Europe/LondonThree Dimensional Printing of Biodegradable Cardiovascular

Rapid advances in three dimensional (3D) printing, whether based on extrusion or lithography, are bringing the technology closer to clinical use in tissue engineering.  3D printing allows for precise bulk geometry and interior architecture control.  Based upon material selection, the resolution of the interior and bulk geometry can typically range from 25 µm to 100 µm.  Using 3D printing, we have developed biodegradable scaffolds with custom pore sizes.  These scaffolds have been non-destructively analyzed with microcomputed tomography to calculate changes in scaffold pore size, porosity, and wall thickness during a 16 week degradation study.  One potential clinical application of 3D printing is for the treatment of cardiovascular diseases, through which outcomes may be drastically improved with custom fabrication of patient-specific grafts.  Current clinical strategies rely upon surgeons constructing tailor-made implants during surgery with generic grafts.  Advancements in imaging technologies, such as MRI and CT, allow for the production of high-quality 3D images from which patient-specific grafts and implants can be generated prior to surgery.  To this end, we have formulated a poly(propylene fumarate) (PPF) based resin to 3D print vascular features with mechanical properties similar to native blood vessels.  The grafts support the growth of vascular cells in vitro and support good neotissue formation after one and three months in vivo.  Further, these grafts may be modified with biomolecules, such as VEGF, so as to recruit and mobilize endothelial cell populations and thus quicken graft endothelialization.

Add to Calendar ▼2015-02-09 00:00:002015-02-10 00:00:00Europe/LondonEmerging Themes and Technologies in Tissue Engineering and