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SELECTBIO Conferences Liquid Biopsies and Minimally-Invasive Diagnostics 2017

Yoon-Kyoung Cho's Biography

Yoon-Kyoung Cho, Professor, Ulsan National Institute of Science & Technology; Group leader, IBS

Yoon-Kyoung Cho is currently Professor in Biomedical Engineering at UNIST and a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS), Republic of Korea. She received her Ph.D. in Materials Science and Engineering from the University of Illinois at Urbana-Champaign in 1999, having obtained her M.S. and B.S. in Chemical Engineering from POSTECH in 1994 and 1992, respectively. She worked as a senior researcher (1999–2008) at Samsung Advanced Institute of Technology (SAIT), where she participated in the development of in vitro diagnostic devices for biomedical applications. Since she joined UNIST in 2008, she has been the chair of the school of Nano-Bioscience and Chemical Engineering (2008–2014) and the school of Life Sciences (2014–2015) and the director of World Class University (2009–2013) and BK21 (2013–2015) programs. She named a Fellow of the Royal Society of Chemistry in 2016. Her research interests range from basic sciences to translational research in microfluidics and nanomedicine. Current research topics include a lab-on-a-disc for the detection of rare cells and biomarkers, quantitative analysis of single cells, and systems analysis of cellular communication.

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Liquid Biopsy of Solid Tumors on a Spinning Disc

Thursday, 5 October 2017 at 15:00

Add to Calendar ▼2017-10-05 15:00:002017-10-05 16:00:00Europe/LondonLiquid Biopsy of Solid Tumors on a Spinning DiscLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island,

In this presentation, our recent efforts on the liquid biopsy application for personalized cancer diagnostics will be discussed in detail. First, we will introduce the fluid-assisted separation technology (FAST), where the size-based separation event occurs not in conventional liquid-gas interface but in liquid-liquid interface stably prepared in a centrifugal microfluidic device. This provides ultrafast, uniform, clog-free, and highly efficient filtration with pressure drop much less than in conventional filtration. We used the FAST mechanism for enriching circulating tumor cells (CTCs) from whole blood without prior sample treatment and could achieve highly sensitive (>95.9% recovery), selective (~3.0 log depletion of white blood cells), rapid (< 3 mL/min), and label-free enumeration of rare CTCs. We demonstrate the clinical utility of the point-of-care detection of CTCs with samples taken from patients suffering from breast, stomach, or lung cancer. Next, we will present a rapid, label-free, and highly sensitive method for Extracellular vesicles (EVs) isolation and quantification using a lab-on-a-disc integrated with two nanofilters (Exodisc). Urinary EVs from bladder cancer patients could be automatically enriched within 30 min using a tabletop-sized centrifugal microfluidic system followed by molecular analysis or on-chip ELISA. We believe that this revolutionary method can contribute to accelerate the acceptance of CTC or EV-based cancer diagnostics as a standard practice in clinical settings.

Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2017Liquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island,