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SELECTBIO Conferences Targeted Cancer Therapies & Biofluid Biopsies

Olivier Pardo's Biography



Olivier Pardo, Team Leader, Imperial College London

Dr Olivier E. Pardo graduated from the Faculty of Pharmacy Paris-V, France where he was awarded a Doctorate in Industrial Pharmacy (1997) and then moved to the UK where he completed his PhD at Imperial College-London (2002). He subsequently joined the laboratory of Prof. Julian Downward at the CRUK-London Research Institute as a post-doctoral fellow where he worked on apoptosis and cell migration. In 2006, he became team leader at Imperial College-London, Department of Surgery and Cancer where he created the Cellular Regulatory Networks lab. His team focuses on understanding the molecular mechanisms underlying chemo-resistance and metastasis in lung and other cancers.

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NRF2-mediated changes in Glutathione Metabolism mediate the resistance of EGFR-T790M Mutant Lung Cancer Cells to Erlotinib

Friday, 26 May 2017 at 11:35

Add to Calendar ▼2017-05-26 11:35:002017-05-26 12:35:00Europe/LondonNRF2-mediated changes in Glutathione Metabolism mediate the resistance of EGFR-T790M Mutant Lung Cancer Cells to ErlotinibTargeted Cancer Therapies and Biofluid Biopsies in BengaluruBengaluruSELECTBIOenquiries@selectbiosciences.com

The speaker will discuss about Metabonomics profiling of erlotinib-sensitive/resistant cells along with how, by using RNA interference and pharmacological inhibitors of GSH pathway enzymes, increasing GSH levels in ER cells sensitises these to erlotinib. Conversely, reducing GSH levels renders sensitive cells resistant to the drug. It will finally highlight how their data identifies a new resistance mechanism to EGFR TKIs and propose a novel therapeutic strategy to tackle this problem in the clinic.


Add to Calendar ▼2017-05-25 00:00:002017-05-26 00:00:00Europe/LondonTargeted Cancer Therapies and Biofluid BiopsiesTargeted Cancer Therapies and Biofluid Biopsies in BengaluruBengaluruSELECTBIOenquiries@selectbiosciences.com