Martyn Boutelle,
Professor of Biomedical Sensors Engineering,
Imperial College London
Martyn Boutelle is Professor of Biomedical Sensors Engineering in the Department of Bioengineering, Imperial College London, and Associate Provost for Estates Planning for Imperial College.
His research group is multidisciplinary comprising, bioengineers, scientists, and clinicians. He develops novel analytical science methods using microfluidics, electrochemical sensors / biosensors, and wireless electronics to make portable (sometimes wearable) monitoring devices for use as point of care devices that typically giving continuous real -time displays. He then uses these in a program of clinical science research focusing on the acute traumatic brain injury including that caused by cardiac arrest, neonatal continuous monitoring and kidney transplantation monitoring. He runs the EPSRC funded Bio-nanofabrication suite designed to make microfluidic and biosensor biosensors using scalable methods to allow use in proof-of-concept clinical trials.
Martyn is past president of the International Society for Monitoring Molecules in Neuroscience, and a founder of the COSBID organization for studying acute human brain injury. He published > 190 papers, chapters and patents. He obtained a BSc and PhD in Chemistry from Imperial College and worked as an EP Abraham Research Fellow in the University of Oxford.
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Wearable Microfluidics For Real-Time Personal MonitoringMonday, 1 October 2018 at 14:30 Tissue functions at a cellular level by exchange of molecules either between cells and blood or between the cells themselves. This produces patterns of molecular change that are diagnostic of cellular processes whose origin can be physiological (exhaustion, pregnancy) or pathological (ischemia, renal failure, cancer). Our technologies have now developed to a point where we can aspire to do more than this, to measure from patients in real-time. The has the great benefit that it is them possible to understand the evolution of disease, the effectiveness of treatments, and ultimately to guide treatment. In this presentation I will describe the development of microfluidic devices connected to wireless electronics for transplant organ, patient and athlete monitoring. Tissue sampling is via an integrated microfluidic device, a microdialysis probe. Molecular biomarkers are measured using microscale integrated amperometric biosensors and solid-contact ion-selective electrodes (ISE) for tissue ionic balance. For detailed patterns of ionic responses we have developed high density Field Effect Transistor (FET) array which function as ISEs within the flow stream. We have also edevelodp multiphase flow microfluidic systems for highest time resolution.The presentation with describe the design and optimization challenges and include clinical examples from our recent work.
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