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SELECTBIO Conferences RNAi and miRNA

Gunter Meister's Biography



Gunter Meister, Professor, University of Regensburg

Gunter Meister is professor and chair for Biochemistry at the University of Regensburg, Germany. He obtained his PhD in 2002 from the Max-Planck-Institute of Biochemistry in Martinsried, Germany. From 2003 to 2005 he worked as postdoctoral fellow in the lab of Tom Tuschl at the Rockefeller University in New York, USA. In 2005, he started his own lab at the Max-Planck-Institute of Biochemistry as independent group leader. In 2009, he was appointed full professor and chair for Biochemistry at the University of Regensburg. His research focus is the biochemical analysis of small RNA-guided gene silencing pathways in mammals.

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Protein and RNA Interactors of Human Argonaute Proteins

Tuesday, 4 September 2012 at 14:45

Add to Calendar ▼2012-09-04 14:45:002012-09-04 15:45:00Europe/LondonProtein and RNA Interactors of Human Argonaute ProteinsSELECTBIOenquiries@selectbiosciences.com

microRNAs (miRNAs) are small non-coding RNAs that function in literally all cellular processes. miRNAs interact with Argonaute (Ago) proteins and guide them to specific target sites located in the 3’ untranslated region (UTR) of target mRNAs leading to translational repression and deadenylation-induced mRNA degradation. Most miRNAs are processed from hairpin-structured precursors by the consecutive action of the RNase III enzymes Drosha and Dicer. However, processing of miR-451 is Dicer-independent and cleavage is mediated by the endonuclease Ago2. Here we have characterized miR-451 sequence and structure requirements for processing as well as sorting of miRNAs into different Ago proteins.


Add to Calendar ▼2012-09-04 00:00:002012-09-05 00:00:00Europe/LondonRNAi and miRNASELECTBIOenquiries@selectbiosciences.com