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SELECTBIO Conferences Organ-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo Functions

Martin Stelzle's Biography

Martin Stelzle, Head of BioMEMS & Sensors Department, NMI at University of Tübingen

Head of the physical chemistry & sensors group since 2000. His research interests include BioMEMS for diagnostics and therapy, sensors, functional biocompatible coatings as well as surface sensitive analytical measurement techniques. Dr. Stelzle studied physics and biophysics at the University of Erlangen and the Technical University Munich.

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Towards Organs-on-Chip Devices in Multiwell Format for Drug Testing, Mechanistic Studies, and Personalized Medicine

Friday, 8 July 2016 at 11:30

Add to Calendar ▼2016-07-08 11:30:002016-07-08 12:30:00Europe/LondonTowards Organs-on-Chip Devices in Multiwell Format for Drug Testing, Mechanistic Studies, and Personalized

Organs-on-chip are envisioned to enable in vivo like answers in preclinical drug testing by establishing cell cultures mimicking the smallest functional units of an organ. We will report on our organs-on-chip technology based on combining microfluidics and dielectrophoresis (DEP) to assemble primary human cells and enabling the automated in vitro construction of micro-organs. As a unique feature of this organ-on-chip technology, the use of DEP selectively assembles only viable cells. Organ-specific 3D cell culture chambers are designed and validated by multiphysics simulations and realized by injection molding of cyclic olefin polymer (COP). Proprietary surface functionalization enables selective deposition of extracellular matrix proteins in a simple perfusion process. High resolution optical imaging of micro-organs along with typical staining technologies can be applied due to the exceptional optical properties of COP. In addition, perfundates and lysates may be collected for biochemical analysis. A particular focus is placed on the design of devices in multiwell plate format in combination with a dedicated periphery system in order to enable assembly and cultivation of multiple micro-organs per chip and integration of the system into existing workflows. In summary, this technology is applicable to the assembly and culture of diverse organ tissues involving complex arrangement of multiple cell types and extracellular matrix and enables continuous perfusion of these micro-organs. A large number of applications in drug testing, mechanistic studies, and in personalized medicine are envisioned to benefit from this technology.

Add to Calendar ▼2016-07-07 00:00:002016-07-08 00:00:00Europe/LondonOrgan-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo