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SELECTBIO Conferences Fragment Based Lead Discovery

Isabelle Krimm's Biography

Isabelle Krimm, Researcher, University of Lyon

Dr Isabelle Krimm is currently working in the CNRS, University of Lyon, France. She obtained her PhD on structural biology studies of thioredoxine-dependent enzymes and toxins by NMR. she Then joined the Commissariat à l’Energie Atomique to study lamin proteins by heteronuclear NMR. She obtained a CNRS position in 2002 and studied protein structures. Her current research focuses on fragment-based protein-ligand interactions by NMR, both for drugdiscovery and chemical biology.

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NMR Characterization of Protein-Fragments Complexes

Tuesday, 19 March 2013 at 14:15

Add to Calendar ▼2013-03-19 14:15:002013-03-19 15:15:00Europe/LondonNMR Characterization of Protein-Fragments Complexes

NMR represents a powerful method to analyse protein-ligand complexes. Here, ligand-observed NMR experiments are used (1) to characterize allosteric enzymes and (2) to compare the binding mode of fragments without resolving the full 3D structure of the complex.    

Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonFragment Based Lead Discovery