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SELECTBIO Conferences Biofluid Biopsies

Jan Lötvall's Biography

Jan Lötvall, Professor, University of Gothenburg; Founding President of ISEV; Editor-in-Chief, Journal of Extracellular Vesicles

Jan Lötvall is Professor of Allergy in Gothenburg, Sweden, but has over the last more than ten years focused a majority of his research efforts on exosomes and other extracellular vesicles. Lötvall showed, in 2007, that exosomes shuttle RNA from one cell to another, which at the time was against all knowledge at the time, but is now considered a novel cell communication pathway. Lötvall also helped the International Society for Extracellular Vesicles in 2011, and was its first president until 2016. Lötvall served as Chief Scientist at Codiak BioSciences in Cambridge, MA, between May 2016-Jan 2018. He is now focusing his academic research on translating EVs to clinical utilization.

Jan Lötvall Image

Exosomes and Other Extracellular Vesicles as Future Extracellular RNA Biomarkers

Tuesday, 28 October 2014 at 14:15

Add to Calendar ▼2014-10-28 14:15:002014-10-28 15:15:00Europe/LondonExosomes and Other Extracellular Vesicles as Future Extracellular RNA

Most cells have the capacity to release different types of extracellular vesicles, that typically have an intact cell membrane which protects the cytoplasmic vesicular cargo. These extracellular vesicles include exosomes, microvesicles as well as apoptotic bodies, where the exosomes are the true nano-sized vesicles, with a diameter of 40-100 nm. In 2007, we discovered that exosomes released from mast cells contain both microRNA and mRNA, which subsequently can be transferred from one cell to another to mediate biological effect. Subsequently, it has been shown that exosomes are present in all human body fluids investigated, including serum, plasma, saliva, semen and breast milk. Importantly, the RNA content in exosomes changes when the cells undergo for example oxidative stress, or are transformed to malignant cells.  Importantly, different extracellular vesicles contain different RNA species, as well documented in different studies using different models. Therefore, cell may mediate multiple RNA-mediated signals by shuttling also other extracellular vesicles than exosomes between cells. Also this aspect will be discussed during the presentation.  The exosomal RNA content is also being investigated as biomarkers for different diseases, including malignancies. Several companies are currently investigating the RNA content of exosomes and other extracellular vesicles, to diagnose diseases and to monitor the effects of therapy.  Lastly, exosomes or similar vesicles could be utilized to deliver therapeutic RNAi molecules to diseased cells / tissues.  Thus, siRNA or other RNAi molecules could at least in theory be loaded into exosomes and be delivered either directly into a tumor area to treat that tumor, or systemically if harboring targeting molecules.  Exosomal shuttle RNA promises to be one of the most exciting research field in biology and medicine over the decades to come.

Add to Calendar ▼2014-10-27 00:00:002014-10-28 00:00:00Europe/LondonBiofluid