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SELECTBIO Conferences Exosomes & Liquid Biopsies Europe 2018

Irina Nazarenko's Biography

Irina Nazarenko, Exosome and Tumor Biology Group Leader, University of Freiburg

Irina Nazarenko is head of the Exosome and Tumor Biology Group at the Medical Center University of Freiburg, Germany. The main focus of her group is the role of Extracellular Vesicles (EVs) in metastatic cancer progression and their application in liquid biopsy. Together with her team she is addressing EVs heterogeneity and the relevance of different EV subtypes for metastases. New in vitro system allowing modelling of 3D tumor environment, EVs isolation and study of their function under 3D conditions is one her recent works. She is working on the concept of “high precision liquid biopsy”, addressing the relevance of different EVs subtypes as a biomarker source. Being trained in genetics and molecular biology at the Moscow State University, Irina Nazarenko started to work with EV during her postdoctoral training at the German Cancer Research Center. She is one of the founders of the International Society of Extracellular Vesicles (ISEV) and a founder and general secretary of the German Society of Extracellular Vesicles (GSEV).

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Relevance of EV Heterogeneity For Their Application in Liquid Biopsy

Friday, 26 October 2018 at 17:30

Add to Calendar ▼2018-10-26 17:30:002018-10-26 18:30:00Europe/LondonRelevance of EV Heterogeneity For Their Application in Liquid BiopsyExosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

The need to develop better approaches allowing comprehensive molecular characterization of a progressing tumor has led to the development of the “Liquid Biopsy” concept, which is based on the application of body fluids as a biomarker source. In view on the complexity of blood and availability of components of different origins, including circulating tumor cells, free-circulating nucleic acids and Extracellular Vesicles (EVs), a question of a specific impact of each of these different compartments on the outcome of liquid biopsy-based diagnostic may arise. We address this question comparing amounts of mutated oncogenes in different EV subtypes and in the free-circulating fractions in blood of cancer patients. Our results show that different tumor types at different stages may contain varying portions of potential biomarkers in the free circulating fraction and in different EV subtypes, indicating a potential relevance of a comparative analysis of different blood compartments prior the choice of the most appropriate source and technique for the liquid biopsy-based diagnostic.

Add to Calendar ▼2018-10-24 00:00:002018-10-26 00:00:00Europe/LondonExosomes and Liquid Biopsies Europe 2018Exosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The