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SELECTBIO Conferences Circulating Biomarkers, Exosomes & Liquid Biopsy Europe 2019

Michiel Pegtel's Biography

Michiel Pegtel, Associate Professor, Cancer Center Amsterdam, VU University Medical Center

Dirk Michiel Pegtel is an associate professor at the department of pathology (Amsterdam UMC, location VUmc, The Netherlands) and director of the Amsterdam UMC Liquid Biopsy Center. Michiel conducted his practical training as an undergraduate student at the National Cancer Institute (Bethesda, USA) and obtained a PhD in Immunology at Tufts University Medical School working on virus-induced cancers in collaboration with MIT Broad Institute (Boston, USA). After postdoctoral training at the Netherlands Cancer Institute in basic cell biology, he started the Exosomes Research group at the Amsterdam UMC. Current members of his group study fundamental principles of exosome biogenesis and small RNA biology with the purpose of developing liquid biopsy strategies and using exosomes for therapeutic delivery. For his early discovery on exosomal-transfer of miRNA, Michiel was awarded the Beijerinck Premium from the Royal Dutch Academy of Sciences. Next to his academic work Michiel is an inventor and cofounder of ExBiome a molecular diagnostics start-up.

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Exosomal-miRNA Signatures in Circulation

Thursday, 31 October 2019 at 11:00

Add to Calendar ▼2019-10-31 11:00:002019-10-31 12:00:00Europe/LondonExosomal-miRNA Signatures in CirculationCirculating Biomarkers, Exosomes and Liquid Biopsy Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

The peripheral blood is rich in cell-free microRNAs (miRNA) that are derived from both living and dying cells. A proportion of these miRNAs are protected from RNAses within vesicles including apoptotic bodies, microvesicles and exosomes. In vitro, exosomes can transport miRNAs to recipient cells, which may also occur in vivo although the physiological relevance and molecular mechanisms of cell-cell transfer of miRNAs has not been established. In this presentation I will discuss our clinical studies concerning exosomal miRNAs as cancer biomarkers for therapy response evaluation and the potential of exosomes as therapeutic delivery vehicles.

Add to Calendar ▼2019-10-30 00:00:002019-11-01 00:00:00Europe/LondonCirculating Biomarkers, Exosomes and Liquid Biopsy Europe 2019Circulating Biomarkers, Exosomes and Liquid Biopsy Europe 2019 in Rotterdam, The NetherlandsRotterdam, The