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SELECTBIO Conferences EV-based Diagnostics, Delivery & Therapeutics

Shivani Sharma's Biography



Shivani Sharma, Associate Director, California NanoSystems Institute, California NanoSystems Institute, UCLA

Dr. Shivani Sharma holds a PhD in Biomedical Engineering and is Associate Director at the California NanoSystems Institute (CNSI) at University of California-Los Angeles, California, USA. Her expertise includes developing novel cell and tissue mechanics based biomarkers for cancer detection and chemosensitivity assays; high-resolution structural and mechanical mapping of exosomes, bio-molecules; and single molecule force spectroscopy for diagnostic and drug delivery applications. She leads the nanobiology R&D applications at the Nano & Pico Characterization Lab at CNSI.

She is a founding member of the International Society for Extracellular vesicles (ISEV), has chaired sessions as well as delivered invited talks at several International/National conferences related to exosomes and cancer diagnostics. She currently serves on the Editorial boards for Journal of Extracellular Vesicles and Journal of Circulating Biomarkers. Dr Sharma's work has featured in Chemical & Engineering News, Global Medical Discovery.com, Asia Research News and won the Physical Sciences Entrepreneurship and Innovation Award.

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Rigor and Reproducibility of Extracellular Vesicles: A Nanoscale Perspective

Tuesday, 18 February 2020 at 16:00

Add to Calendar ▼2020-02-18 16:00:002020-02-18 17:00:00Europe/LondonRigor and Reproducibility of Extracellular Vesicles: A Nanoscale PerspectiveEV-based Diagnostics, Delivery and Therapeutics in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Interest in extracellular vesicles (EVs) in biomedical field is rapidly expanding and has raised high hopes towards novel diagnostics and therapeutics. Current biophysical analysis of EVs typically encompass particle density and size distribution determinations using various techniques. However, variabilities in EV isolation methods, and the structural complexity of these biological-nanoparticles (sub-100nm) necessitate more rigorous nanoscale biophysical characterization of single EVs to facilitate more reliable and comparable EV-based assays. Combing scanning probe, super-resolution optical and electron microscopy, our findings demonstrate the effectiveness of orthogonal high-resolution biophysical-biomechanical characteristics of single EVs, not discernable via particle size distributions and counts alone. The assessment of key structural-mechanical parameters identified as morphology, Rms roughness, Young’s modulus, and co-existent non-vesicles within EV isolates, collectively termed ‘EV-nano-metrics’ provides a promising complementary approach towards advanced understanding of the complexity and heterogeneity of EV isolates, with broad implications for enhancing the reliability and reproducibility of EV-analytes  in research and clinical use.


Add to Calendar ▼2020-02-17 00:00:002020-02-18 00:00:00Europe/LondonEV-based Diagnostics, Delivery and TherapeuticsEV-based Diagnostics, Delivery and Therapeutics in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com