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SELECTBIO Conferences Organ-on-a-Chip & Tissue-on-a-Chip Europe 2019

Noo Li Jeon's Biography

Noo Li Jeon, Professor, Seoul National University

Noo Li Jeon is a Professor of School of Mechanical and Aerospace Engineering at Seoul National University (SNU). He studied Materials Science and Engineering at Northwestern University (B.S.) and University of Illinois Urbana-Champagne (Ph.D.). He worked on soft lithography applications in Prof G.M. Whitesides’ laboratory at Harvard University and at Prof M. Toner’s group at Harvard Medical School. He was an Associate Professor at UC Irvine from 2001-2009 in the Department of Biomedical Engineering. In 2009, he moved to Seoul National University to join School of Mechanical Engineering at Seoul National University.

Noo Li Jeon Image

Array of Vascularized Tumor Spheroids on IMPACT Platform

Wednesday, 19 June 2019 at 08:30

Add to Calendar ▼2019-06-19 08:30:002019-06-19 09:30:00Europe/LondonArray of Vascularized Tumor Spheroids on IMPACT PlatformOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

The field of microfluidics-based three-dimensional (3D) cell culture systems is rapidly progressing from academic proof-of-concept studies to valid solutions to real-world problems. Polydimethylsiloxane (PDMS)-based microfluidics platforms have been widely adopted for tumor-on-a-chip systems. However, due to the inherent material limitations that make it difficult to scale-up production, PDMS has not been widely used in standardized commercial applications for preclinical screening testing. In this presentation, injection-molded tumor spheroid chip made of polystyrene (PS) in a standardized 96-well plate format with a user-friendly design. Spontaneous liquid patterning is achievable with high repeatability. To demonstrate the feasibility of the device, we fabricated microvascular networks, carried out tumor spheroid-based migration and invasion assays, and developed a 3D tumor angiogenesis model for drug screening.  This model is easy- and ready-to-use, and suitable for mass-production systems, with the ability to deliver robust and reproducible results. Ultimately, this platform could provide a high-throughput screening test for anti-cancer drugs.

Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019Organ-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The