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SELECTBIO Conferences 3D-Culture, Organoids and Organs-on-Chips 2021

John Wikswo's Biography

John Wikswo, Gordon A. Cain University Professor, A.B. Learned Professor of Living State Physics; Founding Director, Vanderbilt Institute for Integrative Biosystems, Vanderbilt University

John Wikswo is the Gordon A. Cain University Professor at Vanderbilt University and is the founding Director of the Vanderbilt Institute for Integrative Biosystems Research and Education. Trained as a physicist, he received his B.A. degree from the University of Virginia, and his PhD. from Stanford University. He has been on the Vanderbilt faculty since 1977. His research has included superconducting magnetometry, the measurement and modeling of cardiac, neural and gastric electric and magnetic fields, and non-destructive testing of aging aircraft. His group’s current work on organ-on-chips focuses on the development of intelligent well plates that serve as perfusion controllers, microclinical analyzers, and microformulators; developing a blood-brain-barrier and a cardiac tissue construct on a chip; and integrating multiple organs to create a milli-homunculus from coupled organs on chips. As a tenured member of the Departments of Biomedical Engineering, Molecular Physiology & Biophysics, and Physics & Astronomy, he is guiding the development of microfabricated devices, optical instruments, and software for studying how living cells interact with each other and their environment and respond to drugs, chemical/biological agents, and other toxins, thereby providing insights into systems biology, physiology, medicine, and toxicology. He has over 250 publications, is a fellow of seven professional societies, and has received 39 patents.

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What Do We Need to Make Microphysiological Systems Drug Assays Massively Parallel?

Monday, 22 March 2021 at 16:15

Add to Calendar ▼2021-03-22 16:15:002021-03-22 17:15:00Europe/LondonWhat Do We Need to Make Microphysiological Systems Drug Assays Massively Parallel?3D-Culture, Organoids and Organs-on-Chips 2021 in

Organs-on-chips, organoids and coupled microphysiological systems (MPS) will never reach the level of automation possible with single-pass, high throughput screening of million-compound drug libraries using robots for acoustic seeding, feeding, and dosing-of cells or spheroids in 1536 well plates, followed by either end-point imaging or acoustic delivery of media to a mass spectrometer. Nor should they. But one can wonder exactly how many MPS devices could be created, maintained, and analyzed by an appropriate robotic perfusion system. We will describe a convergence of microfluidic, robotic, and analytic technologies that could easily service a thousand organ-chips or 10,000 separate organoids in a 42U telecom rack/incubator, each undergoing different pharmacokinetic exposures and dynamic metabolomic readouts.

Add to Calendar ▼2021-03-22 00:00:002021-03-23 00:00:00Europe/London3D-Culture, Organoids and Organs-on-Chips 20213D-Culture, Organoids and Organs-on-Chips 2021 in