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SELECTBIO Conferences Organ-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo Functions

John Wikswo's Biography

John Wikswo, Gordon A. Cain University Professor, A.B. Learned Professor of Living State Physics; Founding Director, Vanderbilt Institute for Integrative Biosystems, Vanderbilt University

John Wikswo is the Gordon A. Cain University Professor at Vanderbilt University and is the founding Director of the Vanderbilt Institute for Integrative Biosystems Research and Education. Trained as a physicist, he received his B.A. degree from the University of Virginia, and his PhD. from Stanford University. He has been on the Vanderbilt faculty since 1977. His research has included superconducting magnetometry, the measurement and modeling of cardiac, neural and gastric electric and magnetic fields, and non-destructive testing of aging aircraft. His group’s current work on organ-on-chips focuses on the development of intelligent well plates that serve as perfusion controllers, microclinical analyzers, and microformulators; developing a blood-brain-barrier and a cardiac tissue construct on a chip; and integrating multiple organs to create a milli-homunculus from coupled organs on chips. As a tenured member of the Departments of Biomedical Engineering, Molecular Physiology & Biophysics, and Physics & Astronomy, he is guiding the development of microfabricated devices, optical instruments, and software for studying how living cells interact with each other and their environment and respond to drugs, chemical/biological agents, and other toxins, thereby providing insights into systems biology, physiology, medicine, and toxicology. He has over 250 publications, is a fellow of seven professional societies, and has received 39 patents.

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Organs on Chips for Drug development, Toxicology, and Systems Biology: A Distributed yet Interconnected Modular Approach

Thursday, 7 July 2016 at 14:00

Add to Calendar ▼2016-07-07 14:00:002016-07-07 15:00:00Europe/LondonOrgans on Chips for Drug development, Toxicology, and Systems Biology: A Distributed yet Interconnected Modular

Organs-on-chips are undergoing rapid development to better recapitulate in vitro the function of human organs in vivo. Their application to a variety of fields suggests the need to create large numbers of different organs and operate them either independently or interconnected, or both. This places economic and topological constraints on the physical hardware systems that keep these organs alive, monitors their performance, and controls their interaction. A promising approach is to utilize different low-cost modules, made from a simple set of common components, to provide these functions in a plug-and-play manner, thereby spanning the range of applications of organs on chips pursued from organizations as small as a single-investigator biology lab to government toxicology screening programs to pharmaceutical groups evaluating the efficacy and toxicity of drugs and drug cocktails.

Add to Calendar ▼2016-07-07 00:00:002016-07-08 00:00:00Europe/LondonOrgan-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo