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SELECTBIO Conferences Disease Biomarkers

Paul Tempst's Biography

Paul Tempst, Professor, Memorial Sloan-Kettering Cancer Center

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Aminopeptidase Activities as Biomarkers for Cancer

Thursday, 10 May 2012 at 16:00

Add to Calendar ▼2012-05-10 16:00:002012-05-10 17:00:00Europe/LondonAminopeptidase Activities as Biomarkers for Cancer

Using mouse models for prostate cancer, we discovered an inhibitory activity of dipeptidyl aminopeptidases (DPPs) in animals with aggressive disease. The affected enzyme was identified and shown to be similarly inhibited in sera of patients with metastatic tumors. When used in combination with PSA, the newly developed DPP activity-based assay improves disease stratification over PSA alone.

Add to Calendar ▼2012-05-10 00:00:002012-05-11 00:00:00Europe/LondonDisease