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SELECTBIO Conferences Circulating Nucleic Acids and Circulating Rare Cells: Liquid Biopsy for Early Cancer Detection

Anindya Dutta's Biography



Anindya Dutta, Harry F. Byrd Professor and Chair of Biochemistry and Molecular Genetics and Professor of Pathology, University of Virginia School of Medicine

Dr. Dutta is the Harry F. Byrd Professor and Chair of Biochemistry and Molecular Genetics and Professor of Pathology at the University of Virginia School of Medicine. He has trained at Christian Medical College, Vellore (M.B.B.S.), Rockefeller University (Ph.D.), Cold Spring Harbor Laboratory (Postdoctoral Fellow) and Brigham and Women's Hospital, Harvard Medical School (Residency in Pathology). He was Asst. and Assoc. Professor of Pathology at BWH before moving to UVA. His research interests cover genomic instability in cancer cells and noncoding RNAs in differentiation and cancer. His research interests cover genomic instability in cancer cells and noncoding RNAs in differentiation and cancer.

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Circulating Circulome: A New Source of DNA For Liquid Biopsy?

Thursday, 29 March 2018 at 13:30

Add to Calendar ▼2018-03-29 13:30:002018-03-29 14:30:00Europe/LondonCirculating Circulome: A New Source of DNA For Liquid Biopsy?SELECTBIOenquiries@selectbiosciences.com

Cell-free circulating linear DNA is becoming very important for liquid biopsy. We have discovered small extrachromosomal circular DNA (eccDNA), called microDNA, in the nuclei of mammalian tissues and cell lines. Cell-free microDNAs from uniquely mapping regions of the genome are detected in plasma and serum from both mice and humans.  The cell-free circulating circles are significantly longer (30%-60% >250 bases) than cell-free circulating linear DNA (~150 bases). Tumor-derived human microDNA is detected in the mouse circulation in a mouse xenograft model of human ovarian cancer. Human lung cancers contain longer microDNA than normal lung and these may be detected in the blood. Thus, circular DNA in the circulation is a previously unexplored pool of nucleic acids that could complement miRNAs and linear DNA in liquid biopsies.


Add to Calendar ▼2018-03-28 00:00:002018-03-29 00:00:00Europe/LondonCirculating Nucleic Acids and Circulating Rare Cells: Liquid Biopsy for Early Cancer Detection SELECTBIOenquiries@selectbiosciences.com