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SELECTBIO Conferences Genomics Research Asia

Jingde Zhu's Biography

Jingde Zhu, Principle Investigator, Shanghai Jiaotong University

Jingde Zhu, Ph.D (1985) in molecular pathology from Beatson Institute for Cancer Research, Glasgow, UK and worked as a senior scientist or PI in Shanghai Institute of Cell Biology, three academic institutions and one biotech firm in UK between 1985-2001. His research focuses at the epigenetic (-omic) perspectives (DNA methylation in particular) of biological behavor of cancer and its detetion. He is the inventor for both approved and filed patents (six) in China and in US. He is actively promoting the regional and global epigenome efforts.

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DNA Methylation Perspectives of Cancer Biology and Clinical Management

Tuesday, 12 November 2013 at 09:00

Add to Calendar ▼2013-11-12 09:00:002013-11-12 10:00:00Europe/LondonDNA Methylation Perspectives of Cancer Biology and Clinical ManagementGenomics Research Asia in

Cancer is the disease of misproliferating cells, with a wide range of genetic and epigenetic abnormalities. Among the epigenetic entities, DNA methylation is the best characterized and contributes to the transmission of the long-lasting transcription memory through cell division and therefore the phenotype. Aberrant DNA methylation changes the genomic transcription, representing promising molecular targets for better cancer diagnostics and therapeutics. Using an integrative approach (1. Discovery of the cancer specific altered genes via the MBD-seq based methylomic and RNA-seq based expression profiling, 2. Confirmation of the top candidates by alternative measure in clinical setting and 3. Development of the tailored assay for clinical use), we have developed a novel diagnostic (a multiplex qPCR kit/ DNA methylation profiling of 5 targets in urine sediment) for early detection, quality control of surgery and monitoring the recurrence of bladder cancer. The effort to develop the robust DNA methylation analysis assay in plasma will also be presented.

Add to Calendar ▼2013-11-12 00:00:002013-11-13 00:00:00Europe/LondonGenomics Research AsiaGenomics Research Asia in