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SELECTBIO Conferences Lab-on-a-Chip & Microfluidics World Congress 2019

Abraham Lee's Biography

Abraham Lee, William J. Link Professor and Chair, University of California-Irvine

Abraham (Abe) P. Lee is Professor in the Biomedical Engineering (BME) Department with a courtesy appointment in Mechanical and Aerospace Engineering (MAE) at the University of California, Irvine. He is the Director of the NSF I/UCRC “Center for Advanced Design & Manufacturing of Integrated Microfluidics” (CADMIM). Prior to UCI, he was at the National Cancer Institute and a program manager in the Microsystems Technology Office at DARPA (1999-2001). Dr. Lee’s lab focuses on developing active integrated microfluidics and droplet microfluidic platforms. These platforms are applied to point-of-care and molecular diagnostics, “smart” nanomedicine for early detection and treatment, single cell processing and analysis, and tissue engineering and cell-based therapeutics. His research has contributed to the founding of several start-up companies. Dr. Lee serves as an associate editor for the Lab on a Chip journal and he is also an advisor to companies and government agencies. He owns 42 issued US patents and is author of over 100 journals articles. Professor Lee was awarded the 2009 Pioneers of Miniaturization Prize and is an elected fellow of the National Academy of Inventors, the American Institute of and Medical and Biological Engineering and the American Society of Mechanical Engineers.

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Circulatory System on a Chip -- From in vitro to in vivo, From Single Cell to Microphysiological Systems

Tuesday, 8 October 2019 at 16:30

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The circulatory system is a critical physiological process of the human body that maintains homeostasis by balancing biological parameters by the delivery and removal of nutrients/waste and fighting off invading pathogens.  Through the advancement of microfluidics technologies, we have enabled the automation of biological fluids delivery through physiological vasculature networks that mimic the physiological circulation of the human body.  The critical bottleneck is to engineer the microenvironment for the formation of 3D tissues and organs and to also pump and perfuse the tissue vascular network for on-chip microcirculation.  On the other hand, microfluidics play an important role in the recent advances in liquid biopsy, an emerging technique that analyzes biological samples such as blood for the detection of biomolecules or cells that are indicative of disease or physiological state.  Specifically, liquid biopsy has become a promising technology to isolate and target rare cells such as circulating tumor cells (CTCs) in body fluids thanks to many of these microfluidic cell sorting techniques.  This advent of microfluidic liquid biopsy provides an in vitro snap shot into the patient’s physiological status via the in vivo circulation that enables one to monitor disease state and progression for diagnosis and prognosis. A key bottleneck is to identify the critical subpopulation of cells, often at single cell resolution among billions of cells in circulation. Along with the aforementioned in vitro on-chip perfused vascularized tissue platforms, these two technologies go hand-in-hand to connect in vitro screening to in vivo screening with great potential in the development of personalized medicine.  Ultimately this is the microfluidic maintenance of physiological equilibrium, or ‘microfluidic homeostasis.'

Add to Calendar ▼2019-10-07 00:00:002019-10-09 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics World Congress 2019Lab-on-a-Chip and Microfluidics World Congress 2019 in Coronado Island, CaliforniaCoronado Island,