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SELECTBIO Conferences Organ-on-a-Chip Conference

Thomas Corso's Biography

Thomas Corso, Chief Technical Officer, CorSolutions

Thomas Corso, Ph.D. is Chief Technical Officer at CorSolutions, where he is responsible for R&D, engineering and manufacturing of support instrumentation for BioMEMS and microfluidic applications. His expertise resides in analytical instrumentation development, and the commercialization of innovative solutions. Prior to joining CorSolutions, Dr. Corso led the R&D efforts for a BioMEMS device used in conjunction with mass spectrometers for chromatography separations and electrospray applications. Dr. Corso has over 30 patents and numerous publications in the area of BioMEMs and microfluidics. He served on the user committee at the Cornell NanoScale Science and Technology Facility (CNF) for many years. Dr. Corso received his Ph.D. from Cornell University supported by a National Institutes of Health fellowship award working in the areas of high-precision isotope ratio mass spectrometry and ion trap mass spectrometry. Dr. Corso received a B.A. in music and a B.S. in biochemistry from the University of New Hampshire.

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Solutions for Microfluidics: Precision Fluid Control, Novel Interconnects and Alternatives to the Classical Incubator

Wednesday, 8 July 2015 at 13:30

Add to Calendar ▼2015-07-08 13:30:002015-07-08 14:30:00Europe/LondonSolutions for Microfluidics: Precision Fluid Control, Novel Interconnects and Alternatives to the Classical

For “cells-on-a-chip” approaches to become adopted as an industry standard, the support hardware surrounding these microfluidic devices must be developed and standardized.  Current areas of difficulty include making connections to the microdevices, as well as providing controlled and precise fluid delivery.  We report here a novel interconnect technology for coupling microfluidic, “cells-on-a-chip” devices with pumps and detectors of the macro-world.   The interconnects offer reliability, compatibility with all substrate materials, ease-of-use with little training, flexibility for use with chips having varied architectures, chemical compatibility, allowance of maximum field of view for optical assessment, and have potential for automation.   Additionally we will show a means for providing accurate flow control to the cultures on-chip.  With the critical role that flow rate plays on the cell seeding process used to establish a microfluidic culture and on shear stress in maintaining cultures, it is advantageous to have a highly accurate means of fluidic control.  It will be shown that when Human Umbilical Vein Endothelial Cells (HUVECs) are seeded onto optically transparent flow cells and subjected to controlled shear stress, the cells align, in the direction of flow, in response to the controlled laminar flow of media as delivered by the pump.  The approach allows for re-circulating media through the on-chip cultures for the duration of the experiment.  Finally the integration of pumps and connectors into a platform capable of providing a unique means of environmental control, as an alternative to a classical incubator, will be discussed.

Add to Calendar ▼2015-07-08 00:00:002015-07-09 00:00:00Europe/LondonOrgan-on-a-Chip