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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches

Thomas Corso's Biography

Thomas Corso, Chief Technical Officer, CorSolutions

Thomas Corso, Ph.D. is Chief Technical Officer at CorSolutions, where he is responsible for R&D, engineering and manufacturing of support instrumentation for BioMEMS and microfluidic applications. His expertise resides in analytical instrumentation development, and the commercialization of innovative solutions. Prior to joining CorSolutions, Dr. Corso led the R&D efforts for a BioMEMS device used in conjunction with mass spectrometers for chromatography separations and electrospray applications. Dr. Corso has over 30 patents and numerous publications in the area of BioMEMs and microfluidics. He served on the user committee at the Cornell NanoScale Science and Technology Facility (CNF) for many years. Dr. Corso received his Ph.D. from Cornell University supported by a National Institutes of Health fellowship award working in the areas of high-precision isotope ratio mass spectrometry and ion trap mass spectrometry. Dr. Corso received a B.A. in music and a B.S. in biochemistry from the University of New Hampshire.

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A Benchtop Microfluidic Platform for Culturing Tissue with Live Imaging Under Physiological Flow Conditions

Monday, 10 July 2017 at 14:30

Add to Calendar ▼2017-07-10 14:30:002017-07-10 15:30:00Europe/LondonA Benchtop Microfluidic Platform for Culturing Tissue with Live Imaging Under Physiological Flow

To date, tissue culture with live imaging under physiological flow conditions is challenging.  To address these difficulties CorSolutions has developed a Benchtop Microfluidic Culture Platform for studying tissue culture under physiologically relevant conditions outside of an incubator.  This flexible, universal platform incorporates fluidic interconnects, pulse-free fluid delivery pumps, and optics to offer a simple alternative to the conventional incubator.  The Benchtop Microfluidic Culture Platform can interface a variety of microfluidic devices to the macro world.  To evaluate the platform, perfused microvessels consisting of human umbilical cord vascular endothelial cells, expressing green fluorescent protein, were cultured.  The approach allowed for live cell imaging while subjecting the culture to the physiological shear stress of 15 dynes/cm2, throughout the 3 day experiment.  The results showed an unexpected active migration of cells both with and against the flow, including traversal of the branching channels, and their eventual alignment and polarization in the direction of flow.  The live imaging revealed cell behavior that had never before been observed as endothelial cells had been believed to be quiescent, undergoing mitosis only once every one to two years.  Although the implications of the observed cell migrations are not yet known, it is clear that the Benchtop Microfluidic Culture Platform is a tool with tremendous potential for probing cellular behavior.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and