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SELECTBIO Conferences Circulating Biomarkers 2014

Dominique PV de Kleijn's Biography



Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands

Prof. Dr. Dominique PV de Kleijn is a molecular biologist and chemist, and professor of Experimental Vascular Surgery at UMC Utrecht and professor at the Netherlands Heart Institute. From 2012 to 2016, he was Research Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI) Singapore. He was until 2016 professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht. Since 1997 he is coordinating cardiovascular research from basic science, animal myocardial infarction and atherosclerotic studies (mouse and pig) towards clinical biobanking studies. His research interests are: The innate immune system in cardiovascular disease and atherosclerosis & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles. He has more than 200 publications and a H-factor of 68.

Dominique PV de Kleijn Image

Plasma Vesicle Proteins in Diagnosis and Prognosis of cardiovascular Disease

Monday, 24 March 2014 at 09:45

Add to Calendar ▼2014-03-24 09:45:002014-03-24 10:45:00Europe/LondonPlasma Vesicle Proteins in Diagnosis and Prognosis of cardiovascular DiseaseCirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts, USASELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles, including microvesicles, microparticles and exosomes are abundant in plasma. All cells secrete extracellular vesicles that can be easily isolated from frozen plasma or serum and contain part of its cellular content like protein, miRNA and RNA. For this, interrogating extracellular vesicles content is like looking at a sample from the (pathological) cell they originate from. Vesicle content therefore contains information on pathological status that can be used for diagnosis and prognosis of disease. Isolating these vesicles from the blood and studying their content may provide rapid information on the pathological status of tissues. We already established that plasma extracellular vesicles can be used for the diagnosis of Acute Coronary Syndrome in an emergency department cohort of 471 patient with chest pain and prediction of secondary cardiovascular events on top of existing risk factors in 1100 patients.
We now established that plasma vesicle proteins in adult cohorts are associated with adiposity, the number of total affected vascular territories and with carotid intima-media thickness in a children cohort.
This shows that plasma extracellular vesicle proteins reflects the status of cardiovascular disease and are an important source for diagnostic and prognostic markers for this rapidly growing disease that is responsible for the number 1 and 2 cause death in the world.


Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts, USASELECTBIOenquiries@selectbiosciences.com