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SELECTBIO Conferences Circulating Biomarkers World Congress 2015

Dominique PV de Kleijn's Biography



Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands

Professor de Kleijn is Professor of Experimental Vascular Surgery at UMC Utrecht and Professor of the Netherlands Heart Institute, Utrecht The Netherlands. From 2012 to 2016, he was Research Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI) Singapore. He was until 2016 professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht. Since 1997 he is coordinating cardiovascular research from basic science, animal myocardial infarction and atherosclerotic studies (mouse and pig) towards clinical biobanking studies. Next to this, he is CTO of a UMC Utrecht spin-off biomarker company Cavadis BV and member of the Scientific Committee of ICIN and initiator and founder SOciety for Clinical Research and Translation of Extracellular Vesicles Singapore ”SOCRATES”. His research interests are: The innate immune system in cardiovascular disease and atherosclerosis & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles.

Dominique PV de Kleijn Image

Isolation and Characterization of Plasma Extracellular Samples from Clinical Plasma Samples

Monday, 23 March 2015 at 15:00

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Easy, cheap, efficient and reproducible isolation of plasma extracellular vesicles is a necessity when processing large numbers of clinical samples in cohort studies.  Especially for cardiovascular disease large patient numbers are often needed to validate plasma vesicle markers to show their added value on top of risk factor models.  Classical methods like ultracentrifugation are often too time-consuming, expensive and use too large volumes of precious plasma samples.  Alternative methods suitable for larger sample numbers and smaller samples are discussed focusing on methods used in cardiovascular disease like: precipitation, column purification or flow cytometry to interrogate clinical samples with biomarkers for diagnosis and prognosis of disease.


Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonCirculating Biomarkers World Congress 2015Circulating Biomarkers World Congress 2015 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com