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SELECTBIO Conferences Advances in Cellular Assays & Cell Culture

Alvin Nienow's Biography



Alvin Nienow, Professor, University of Birmingham

Alvin W Nienow is Emeritus Professor of Biochemical Engineering at The University of Birmingham, Visiting Professor at Loughborough University and a Fellow of the Royal Academy of Engineering, UK. He has been awarded “The Moulton Medal” and “The Donald Medal” by the Institution of Chemical Engineers; the Jan E Purkyne Medal by the Academy of Sciences of the Czech Republic and the BHRG "Lifetime Recognition Award" by the European Federation of Chemical Engineering. He has an Honorary Doctorate from the West Pomeranian University of Technology, Poland and Loughborough University. He has published over 300 papers in refereed journals and conferences on mixing, especially related to bioprocessing. The topics covered include the effect of mechanical and environmental stress on animal cells, bacteria, yeast, mycelia and stem cells in bioreactors and during cell lysis for gene therapy products; alongside the physical aspects of stirred bioreactors (especially the advantages on new impellers) and their scale-up. He is an editor of the textbook, “Mixing in the Process Industries”, now in its 2nd edition and in paperback and translated into Japanese and Chinese. He also consults for many companies in the UK, Europe and the USA and for The Fluid Mixing Processes Industrial Consortium.

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Scale-down Protocols for Assessing the Impact of Stresses from Agitation on Animal Cell Cultures; Protein Production and Quality

Thursday, 15 May 2014 at 10:45

Add to Calendar ▼2014-05-15 10:45:002014-05-15 11:45:00Europe/LondonScale-down Protocols for Assessing the Impact of Stresses from Agitation on Animal Cell Cultures; Protein Production and QualityAdvances in Cellular Assays and Cell Culture in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

Please note that this presentation will be given by Qasim Rafiq on behalf of Alvin Nienow.

Three studies of four CHO cell cultures in stirred bench scale bioreactors and in a microbioreactor, ambrTM, will be discussed. These scale-down protocols showed that at high mean specific energy dissipation rates (‘high shear’) up to ~ 50 times those normally used in commercial culture, neither cell density, protein yield or protein quality were reduced.


Add to Calendar ▼2014-05-14 00:00:002014-05-15 00:00:00Europe/LondonAdvances in Cellular Assays and Cell CultureAdvances in Cellular Assays and Cell Culture in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com