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SELECTBIO Conferences Circulating Biomarkers, Exosomes & Liquid Biopsy Asia 2019

Sehyun Shin's Biography

Sehyun Shin, Professor & Director, Nano-Biofluignostic Engineering Research Center, Korea University and Anam/Guro Hospital of Korea University

Professor Shin is currently professor of School of Mechanical Engineering and College of Medicine at Korea University and the director of Nano-Biofluignostic Engineering Research Center. He also has served as the Editor of the Journal of Mechanical Science and Technology (JMST). His research interests include the liquid biopsy for cancer and infectious viruses and the development of microfluidic technologies for disease detection, diagnosis and therapy. He has authored more than 150 peer-reviewed papers and delivered more than 130 invited talks and plenary lectures. He is as the president of International Society of Clinical Hemorheology as well as president of Biomedical Engineering Society of Cardiovascular Diseases. Prof. Shin co-founded three startups which are commercializing technologies developed in his lab. He has garnered many research awards and honors including Presidential citation of Science and Technology Merit by the Korean government, award for the Scientist of the month by NRF, the Academic award of KSME, the Nam-Heon Academic Award for Thermal engineering, Fellow of the ISCH, Fellow of KSME and Fellow of KSOR. Finally, Prof. Shin currently heads a group of 15 researchers.

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Innovative Microfluidic Isolation of Circulating Biomarkers: cfDNA and Exosomes

Monday, 9 September 2019 at 11:45

Add to Calendar ▼2019-09-09 11:45:002019-09-09 12:45:00Europe/LondonInnovative Microfluidic Isolation of Circulating Biomarkers: cfDNA and ExosomesCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,

Liquid biopsy, non-invasively analyzing biomarkers circulating in various body fluids, has been emphasized as a promising technology to accelerate the realization of personalized treatment of cancer. Among the circulating biomarkers, cell-free DNA (cfDNA) and exosome have been implicated as important biomarkers in cancer management. Efficient techniques for isolation of such biomarkers from blood are prerequisites for precision liquid biopsy. Also, a sample-to-answer system for such biomarker extraction is highly required for clinical application. Thus, in the present study, two of technologies (PIBEX and PLL clustering) to isolate main circulating biomarkers (cfDNA and exosome) of liquid biopsy are presented. First, the PIBEX system is a centrifugation-free cfDNA extraction microfluidic chip capable of extracting cfDNA from plasma samples through microfluidic circuits within 15 min under vacuum pressure using an immiscible solvent. Second, the PLL clustering method is the microfluidic chip capable of isolating exosomes from plasma samples within an hour under vacuum pressure using a cationic polymer solution. These chips effectively eliminates the repetitive centrifugation processes and dramatically shortened the sample preparation time. The proposed microfluidic platform could facilitate the development of a sample-to-answer system for use in liquid biopsy of cancers.

Add to Calendar ▼2019-09-09 00:00:002019-09-10 00:00:00Europe/LondonCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019Circulating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,